NDLI: Retinoic acid receptor (RAR)-alpha is not critically required for mediating retinoic acid effects in the developing mouse retina.

Please wait, while we are loading the content...

Year: 2017 Volume: 58

Year: 2016 Volume: 57

Year: 2015 Volume: 56

Year: 2014 Volume: 56

Year: 2014 Volume: 55

Year: 2013 Volume: 54

Year: 2012 Volume: 53

Year: 2011 Volume: 52

Year: 2010 Volume: 51

Year: 2010 Volume: 51 Issue: 12

Year: 2010 Volume: 51 Issue: 11

Year: 2010 Volume: 51 Issue: 10

Year: 2010 Volume: 51 Issue: 9

Year: 2010 Volume: 51 Issue: 8

Year: 2010 Volume: 51 Issue: 7

Year: 2010 Volume: 51 Issue: 6

Comparison between macular pigment optical density measurements using two-wavelength autofluorescence and heterochromatic flicker photometry techniques.

Blood-retinal barrier glycerol permeability in diabetic macular edema and healthy eyes: estimations from macular volume changes after peroral glycerol.

Minimal Effects of VEGF and Anti-VEGF Drugs on the Permeability or Selectivity of RPE Tight Junctions

The sensitivity of the 2- to 4-month-old human infant accommodation system.

Biomechanical properties of keratoconus suspect eyes.

The safety of intraocular linezolid in rabbits.

Physicochemical properties affecting retinal drug/coumarin-6 delivery from nanocarrier systems via eyedrop administration.

Age-dependent deamidation of lifelong proteins in the human lens.

Mutation discovered in a feline model of human congenital retinal blinding disease.

Aqueous humor levels of hepatocyte growth factor in retinitis pigmentosa.

Responses of cultured human keratocytes and myofibroblasts to ethyl pyruvate: a microarray analysis of gene expression.

Monoscopic versus stereoscopic retinal photography for grading diabetic retinopathy severity.

Molecular and biochemical characterization of folate transport proteins in retinal Müller cells.

Modulation of inflammatory markers by miR-146a during replicative senescence in trabecular meshwork cells.

Antifibrotic effect of Pirfenidone on orbital fibroblasts of patients with thyroid-associated ophthalmopathy by decreasing TIMP-1 and collagen levels.

Automated quantification and topographical distribution of the whole population of S- and L-cones in adult albino and pigmented rats.

Influence of height, weight, and body mass index on optic disc parameters.

Use of EyeCam for imaging the anterior chamber angle.

Photoreceptor Degeneration, Azoospermia, Leukoencephalopathy, and Abnormal RPE Cell Function in Mice Expressing an Early Stop Mutation in CLCN2

The zebrafish galectin Drgal1-l2 is expressed by proliferating Müller glia and photoreceptor progenitors and regulates the regeneration of rod photoreceptors.

Hydrostatic pressure-induced release of stored calcium in cultured rat optic nerve head astrocytes.

Neuroprotective effect of upregulated sonic Hedgehog in retinal ganglion cells following chronic ocular hypertension.

Effect of Robo1 on retinal pigment epithelial cells and experimental proliferative vitreoretinopathy.

Retinal cell responses to elevated intraocular pressure: a gene array comparison between the whole retina and retinal ganglion cell layer.

Inhibition of cytokine signaling in human retinal endothelial cells through downregulation of sphingomyelinases by docosahexaenoic acid.

Involvement of P2X7 receptors in the hypoxia-induced death of rat retinal neurons.

Prevalence and systemic risk factors for retinal vein occlusion in a general Japanese population: the Hisayama study.

An in vitro intact globe expansion method for evaluation of cross-linking treatments.

Treatment of sheep steroid-induced ocular hypertension with a glucocorticoid-inducible MMP1 gene therapy virus.

Development of a gene therapy virus with a glucocorticoid-inducible MMP1 for the treatment of steroid glaucoma.

Enzymatic Quantification of Cholesterol and Cholesterol Esters from Silicone Hydrogel Contact Lenses

Changes in corneal collagen architecture during mouse postnatal development.

Antipermeability function of PEDF involves blockade of the MAP kinase/GSK/beta-catenin signaling pathway and uPAR expression.

Effect of EGF-induced HDAC6 activation on corneal epithelial wound healing.

Bevacizumab suppression of establishment of micrometastases in experimental ocular melanoma.

Effects of sildenafil and tadalafil on intraocular pressure in sheep: implications for aqueous humor dynamics.

Time-dependent effects of focal retinal ischemia on axonal cytoskeleton proteins.

The psychometric validity of the NEI VFQ-25 for use in a low-vision population.

Immune responses to interphotoreceptor retinoid-binding protein and S-antigen in Behcet's patients with uveitis.

Blood pressure, perfusion pressure, and open-angle glaucoma: the Los Angeles Latino Eye Study.

Detection and quantification of tear phospholipids and cholesterol in contact lens deposits: the effect of contact lens material and lens care solution.

Protein macroarray profiling of serum autoantibodies in pseudoexfoliation glaucoma.

The role of TLR2, TRL3, TRL4, and TRL9 signaling in the pathogenesis of autoimmune disease in a retinal autoimmunity model.

Release of interleukins 6 and 8 induced by zymosan and mediated by MAP kinase and NF-kappaB signaling pathways in human corneal fibroblasts.

Measurement of the time course of optical quality and visual deterioration during tear break-up.

Reduced nitro-oxidative stress and neural cell death suggests a protective role for microglial cells in TNFalpha-/- mice in ischemic retinopathy.

Retinoic acid receptor (RAR)-alpha is not critically required for mediating retinoic acid effects in the developing mouse retina.

Gelatinase expression in retinoblastoma: modulation of LH(BETA)T(AG) retinal tumor development by anecortave acetate.

Aqueous humor dynamics during the day and night in juvenile and adult rabbits.

Association of POAG risk factors and the Thr377Met MYOC mutation in an isolated Greek population.

TSLP and downstream molecules in experimental mouse allergic conjunctivitis.

Duct System of the Rabbit Lacrimal Gland: Structural Characteristics and Role in Lacrimal Secretion

Profile of refractive errors in cerebral palsy: impact of severity of motor impairment (GMFCS) and CP subtype on refractive outcome.

Calpain activation in experimental glaucoma.

Inhibition of matrix metalloproteinase activity in the chick sclera and its effect on myopia development.

The impact of inoculation parameters on the pathogenesis of contact lens-related infectious keratitis.

The mouse model of Down syndrome Ts65Dn presents visual deficits as assessed by pattern visual evoked potentials.

The relationship between demodex and ocular discomfort.

Desiccating stress promotion of Th17 differentiation by ocular surface tissues through a dendritic cell-mediated pathway.

Retinal adaptability loss in serous retinal detachment with central serous chorioretinopathy.

Vision-specific distress and depressive symptoms in people with vision impairment.

Dietary carbohydrate in relation to cortical and nuclear lens opacities in the melbourne visual impairment project.

The mouse retina as an angiogenesis model.

Glucose-6-phosphate-dehydrogenase deficiency as a risk factor for pterygium.

Year: 2010 Volume: 51 Issue: 5

Year: 2010 Volume: 51 Issue: 4

Year: 2010 Volume: 51 Issue: 3

Year: 2010 Volume: 51 Issue: 2

Year: 2010 Volume: 51 Issue: 1

Year: 2009 Volume: 50

Year: 2008 Volume: 49

Retinoic acid receptor (RAR)-alpha is not critically required for mediating retinoic acid effects in the developing mouse retina.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Trensz, Frédéric Jellali, Abdeljalil Ghyselinck, Norbert B. Roux, Michel J. Cammas, Laura Dollé, Pascal
Description	Country affiliation: France Author Affiliation: Cammas L ( Institut de Génétique et de Biologie Moléculaire et Cellulaire, BP 10142 Illkirch, France.)
Abstract	PURPOSE: To determine the functional contribution of retinoic acid receptor (RAR)-alpha in the developing murine neural retina, through a phenotypic analysis of the corresponding null mutants. METHODS: RARalpha mutant (Rara(-/-)) mice were compared with wild-type littermates at several stages of pre- and postnatal development. An RA-response element (RARE)-containing reporter transgene was used to assess the contribution of RARalpha to retinoid signaling in the retina. In situ hybridization was performed on serial eye sections to investigate the expression of main developmental regulators. Immunofluorescence was used to detect differentiated cell types in the adult retina. Mutants were also subjected to clinical observation and visual function evaluation with the optomotor test and electroretinography. RESULTS: Both isoform transcripts of RARalpha were expressed throughout the neural retina at various stages of pre- and postnatal development. In the Rara(-/-) mice the RARE-reporter transgene consistently failed to activate in the developing neural retina. However, they did not exhibit any alteration of the expression patterns of molecular determinants and had a normal organization of retinal cell types at postnatal stages. Their performance in visual tests was indistinguishable from that of control littermates. CONCLUSIONS: Although RARalpha mediates RARE reporter transgene activity in the neural retina, its function is not necessary for the retina to develop and function normally. These data suggest that retinoic acid regulates neural retinal development through other, possibly RAR-independent, pathways.
ISSN	01460404
e-ISSN	15525783
Journal	Investigative Opthalmology & Visual Science
Issue Number	6
Volume Number	51
Language	English
Publisher	Association for Research in Vision and Ophthalmology
Publisher Date	2010-06-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Receptors, Retinoic Acid Physiology Retina Embryology Tretinoin Animals Cell Differentiation Electroretinography Embryonic Development Fluorescein Angiography Fluorescent Antibody Technique, Indirect Gene Expression Regulation Genes, Reporter In Situ Hybridization Mice Mice, Knockout Mice, Transgenic Motor Activity Protein Isoforms Response Elements Metabolism Discipline Ophthalmology
Content Type	Text
Resource Type	Article
Subject	Ophthalmology Sensory Systems Cellular and Molecular Neuroscience

Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302

See location in the Map
03222 282435
Mail: support@ndl.gov.in

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in