NDLI: Comparison between macular pigment optical density measurements using two-wavelength autofluorescence and heterochromatic flicker photometry techniques.

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Comparison between macular pigment optical density measurements using two-wavelength autofluorescence and heterochromatic flicker photometry techniques.

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Comparison between macular pigment optical density measurements using two-wavelength autofluorescence and heterochromatic flicker photometry techniques.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Canovas, Renata Rosen, Richard B. Prata, Tiago S. Lima, Verônica Castro Garcia, Patricia Morini, Chiara
Description	Country affiliation: United States Author Affiliation: Canovas R ( Retina Service, Department of Ophthalmology, The New York Eye and Ear Infirmary, New York, New York 10003, USA.)
Abstract	PURPOSE: The association of macular pigment (MP) with age-related macular degeneration has been extensively studied in recent years, and interest in a rapid, objective, and accurate technique to measure MP optical density (MPOD) has increased. The purpose of this study was to compare the MPOD values at specific loci around the fovea using the heterochromatic flicker photometry (HFP) and the two-wavelength autofluorescence (AF) methods in a young, healthy population. METHODS: Ten patients (20 eyes) were enrolled. Subjects with any ocular or systemic disease were excluded. All patients underwent HFP and AF examination. The AF examination was performed using a modified scanning laser ophthalmoscope. Values for both devices were measured at four eccentricities around the fovea (0.25 degrees , 0.5 degrees, 1.0 degrees, and 1.75 degrees). Each eye was tested three times with each METHOD: Statistical analysis was based on paired t-test and linear regression analysis. RESULTS: At all retinal eccentricities, the HFP values were consistently lower than the HRA values (P < 0.001). There was, however, a significant correlation at almost all locations. The strongest correlation between two methods was found at 1.75 degrees from the center of the fovea (r = 0.73). CONCLUSIONS: The modified-HRA AF method for MPOD generated results that were highly correlated with the standard HPF method but consistently higher at all eccentricities. These findings suggest that HRA can be reliably used in patients unable to perform HPF, which is important for wider clinical application of MP testing.
ISSN	01460404
e-ISSN	15525783
Journal	Investigative Opthalmology & Visual Science
Issue Number	6
Volume Number	51
Language	English
Publisher	Association for Research in Vision and Ophthalmology
Publisher Date	2010-06-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Lutein Photometry Retina Chemistry Spectrometry, Fluorescence Xanthophylls Prospective Studies Visual Acuity Zeaxanthins Comparative Study Discipline Ophthalmology
Content Type	Text
Resource Type	Article
Subject	Ophthalmology Sensory Systems Cellular and Molecular Neuroscience

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