NDLI: The safety of intraocular linezolid in rabbits.

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The safety of intraocular linezolid in rabbits.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Haider, Neena B. Duke, Sara L. Kump, Leila I. Sachs, Andrew J. Margalit, Eyal West, William W. Yuan, Yang
Description	Country affiliation: United States Author Affiliation: Duke SL ( Department of Ophthalmology and Visual Sciences, University of Nebraska Medical Center, Omaha, Nebraska 68198-5540, USA.)
Abstract	PURPOSE: Intraocular injection of linezolid, a synthetic oxazolidinone antibiotic, was performed in rabbits to assess its safety as a possible treatment for endophthalmitis. METHODS: Linezolid, 300 microg/0.1 mL, 200 microg/0.1 mL, or 100 microg/0.1 mL, was injected into the vitreous of the right eye of 12 rabbits. Balanced saline solution was injection into the left eye of each rabbit as a control. A standard electroretinogram (ERG) was obtained before injection and repeated 2 days and 1 and 4 weeks after injection. Intraocular pressure (IOP) was also measured after injection. After the experiment, the rabbits were euthanatized and the retinas were examined by light and electron microscopy. Differences between the two eyes in the ERGs, IOP, and histopathology were recorded. RESULTS: There were no statistically significant differences in the electroretinograms obtained between the linezolid-injected eyes and the control eyes. Histopathology showed no changes in the study eyes compared with the control eyes. CONCLUSIONS: Preservative-free linezolid is nontoxic to the retinas of rabbits when injected intravitreally, and this route can therefore be considered for the administration of linezolid in the treatment of endophthalmitis.
ISSN	01460404
e-ISSN	15525783
Journal	Investigative Opthalmology & Visual Science
Issue Number	6
Volume Number	51
Language	English
Publisher	Association for Research in Vision and Ophthalmology
Publisher Date	2010-06-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Acetamides Toxicity Anti-infective Agents Oxazolidinones Retina Drug Effects Animals Electroretinography Injections Intraocular Pressure Linezolid Microscopy, Electron Rabbits Vitreous Body Research Support, Non-u.s. Gov't Discipline Ophthalmology
Content Type	Text
Resource Type	Article
Subject	Ophthalmology Sensory Systems Cellular and Molecular Neuroscience

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