NDLI: Effect of Robo1 on retinal pigment epithelial cells and experimental proliferative vitreoretinopathy.

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Effect of Robo1 on retinal pigment epithelial cells and experimental proliferative vitreoretinopathy.

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Effect of Robo1 on retinal pigment epithelial cells and experimental proliferative vitreoretinopathy.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Xu, Yongsheng Li, Xiaoxin Chu, Liqun Dong, Jianqiang Yu, Wenzhen Huang, Lvzhen Li, Yingjie
Description	Country affiliation: China Author Affiliation: Huang L ( Department of Ophthalmology, Peking University People's Hospital, Beijing, China.)
Abstract	PURPOSE: The Roundabout (Robo) family of proteins is related to the transmembrane receptors and plays a major role in neurogenesis. However, the role of the Robo proteins in proliferative retinopathy has not yet been defined. This study was conducted to determine whether Robo1 is expressed in the retina of patients with proliferative retinal disease and whether it has a pathobiological role in the disease. METHODS: Immunohistochemistry was used to determine the presence and distribution of Robo1 in the pathologic membranes in proliferative retinopathy. Small interfering (si)RNA technology was used to knockdown Robo1 expression and to study its effects on retinal pigment epithelial (RPE) cells in vitro. The impact on PVR development of blocking Robo1 expression was determined by applying specific siRNA in a PVR rabbit model. The prevalences of PVR and retinal detachment were determined by indirect ophthalmoscope on days 1, 3, 7, 14, 21, and 28 after the injection of RPE cells into the vitreous. RESULTS: Immunohistochemistry showed that Robo1 expression was detected in GFAP-labeled glial cells and cytokeratin-labeled RPE cells in proliferative membranes. Robo1 expression was also detected in CD31-labeled vascular endothelial cells. Knockdown of Robo1 expression not only reduced human RPE cell proliferation in vitro but also effectively suppressed the development of PVR in a rabbit model. CONCLUSIONS: Robo1 is present in the extracellular matrix of proliferative membranes and may be derived from dedifferentiated RPE cells. Silencing the expression of Robo1 in RPE cells inhibited cell proliferation and suppressed the development of PVR in an animal model, indicating a potential therapeutic usefulness in treating PVR.
ISSN	01460404
e-ISSN	15525783
Journal	Investigative Opthalmology & Visual Science
Issue Number	6
Volume Number	51
Language	English
Publisher	Association for Research in Vision and Ophthalmology
Publisher Date	2010-06-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Disease Models, Animal Nerve Tissue Proteins Physiology Receptors, Immunologic Retinal Pigment Epithelium Metabolism Vitreoretinopathy, Proliferative Adolescent Animals Antigens, Cd31 Cell Line Cell Movement Cell Proliferation Diabetic Retinopathy Endothelium, Vascular Enzyme-linked Immunosorbent Assay Epiretinal Membrane Flow Cytometry Fluorescent Antibody Technique, Indirect Gene Silencing Glial Fibrillary Acidic Protein Keratins Neuroglia Rna, Small Interfering Genetics Rabbits Reverse Transcriptase Polymerase Chain Reaction Prevention & Control Research Support, Non-u.s. Gov't Discipline Ophthalmology
Content Type	Text
Resource Type	Article
Subject	Ophthalmology Sensory Systems Cellular and Molecular Neuroscience

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