NDLI: Axonal protection via modulation of the amyloidogenic pathway in tumor necrosis factor-induced optic neuropathy.

Please wait, while we are loading the content...

Year: 2017 Volume: 58

Year: 2016 Volume: 57

Year: 2015 Volume: 56

Year: 2014 Volume: 56

Year: 2014 Volume: 55

Year: 2013 Volume: 54

Year: 2012 Volume: 53

Year: 2012 Volume: 53 Issue: 13

Year: 2012 Volume: 53 Issue: 12

Upregulation of retinal neuronal MCP-1 in the rodent model of diabetic retinopathy and its function in vitro.

The UCP1 -3826A/G polymorphism is associated with diabetic retinopathy and increased UCP1 and MnSOD2 gene expression in human retina.

Analysis of higher-order aberrations in a large clinical population.

Comparison of single versus multiple injections of the protein saratin for prolonging bleb survival in a rabbit model.

The diabetic ocular environment facilitates the development of endogenous bacterial endophthalmitis.

Effects of VIP on corneal reconstitution and homeostasis following Pseudomonas aeruginosa induced keratitis.

Lectin from Agaricus bisporus inhibited S phase cell population and Akt phosphorylation in human RPE cells.

Phosphene thresholds elicited by transcorneal electrical stimulation in healthy subjects and patients with retinal diseases.

Construction of an inexpensive, hand-held fundus camera through modification of a consumer 'point-and-shoot' camera.

Two-year intraocular delivery of ciliary neurotrophic factor by encapsulated cell technology implants in patients with chronic retinal degenerative diseases.

Notch inhibition during corneal epithelial wound healing promotes migration.

Effects of strabismic amblyopia and strabismus without amblyopia on visuomotor behavior, I: saccadic eye movements.

High prevalence of myopia and high myopia in 5060 Chinese university students in Shanghai.

Automated segmentation of the choroid from clinical SD-OCT.

Histamine involvement in visual development and adaptation.

Polymorphisms in ARMS2/HTRA1 and complement genes and age-related macular degeneration in India: findings from the INDEYE study.

Mathematically modeling the involvement of axons in Leber's hereditary optic neuropathy.

Spatial contrast sensitivity vision loss in children with cortical visual impairment.

Balance control in glaucoma.

Structure-function relationship between FDF, FDT, SAP, and scanning laser ophthalmoscopy in glaucoma patients.

Mapping the differential distribution of proteoglycan core proteins in the adult human retina, choroid, and sclera.

Axial elongation following cataract surgery during the first year of life in the infant Aphakia Treatment Study.

Ccl2/Cx3cr1 knockout mice have inner retinal dysfunction but are not an accelerated model of AMD.

Bevacizumab and rapamycin can decrease corneal opacity and apoptotic keratocyte number following photorefractive keratectomy.

Dose-ranging evaluation of intravitreal siRNA PF-04523655 for diabetic macular edema (the DEGAS study).

The role of VIP in cornea.

Induction of Endoplasmic Reticulum Stress Genes, BiP and Chop, in Genetic and Environmental Models of Retinal Degeneration

Relationship between retinal layer thickness and the visual field in early age-related macular degeneration.

The epidemiology and incidence of cytomegalovirus retinitis in the HIV population in Singapore over 6 years.

Improved reproducibility in measuring the laminar thickness on enhanced depth imaging SD-OCT images using maximum intensity projection.

Visual acuity, crowding, and stereo-vision are linked in children with and without amblyopia.

A novel role of complement in retinal degeneration.

Protective effect of carnosic acid, a pro-electrophilic compound, in models of oxidative stress and light-induced retinal degeneration.

Expression and role of VEGF--a in the ciliary body.

Role of hepatocyte growth factor in promoting the growth of human corneal endothelial cells stimulated by L-ascorbic acid 2-phosphate.

Interleukin-6 production in CD40-engaged fibrocytes in thyroid-associated ophthalmopathy: involvement of Akt and NF-κB.

Association between choroidal thickness and ocular perfusion pressure in young, healthy subjects: enhanced depth imaging optical coherence tomography study.

The IS/OS junction layer in the natural history of type 2 idiopathic macular telangiectasia.

Macular choroidal thickness measured by swept source optical coherence tomography in eyes with inferior posterior staphyloma.

Posture-induced intraocular pressure changes in eyes with open-angle glaucoma, primary angle closure with or without glaucoma medications, and control eyes.

Development-related splicing regulates pituitary adenylate cyclase-activating polypeptide (PACAP) receptors in the retina.

Keratitis-associated fungi form biofilms with reduced antifungal drug susceptibility.

Anti-angiogenic effect of luteolin on retinal neovascularization via blockade of reactive oxygen species production.

Aligning scan locations from consecutive spectral-domain optical coherence tomography examinations: a comparison among different strategies.

Pulsatile movement of the optic nerve head and the peripapillary retina in normal subjects and in glaucoma.

Retinal prosthesis safety: alterations in microglia morphology due to thermal damage and retinal implant contact.

Axonal protection via modulation of the amyloidogenic pathway in tumor necrosis factor-induced optic neuropathy.

Relaxin 2 is functional at the ocular surface and promotes corneal wound healing.

Education is positively associated with macular pigment: the Irish Longitudinal Study on Ageing (TILDA).

Repeatability of Spectralis OCT measurements of macular thickness and volume in diabetic macular edema.

Validating a nonhuman primate model of super-selective intraophthalmic artery chemotherapy: comparing ophthalmic artery diameters.

Long-term decline of central cone function in retinitis pigmentosa evaluated by focal electroretinogram.

Dynamic contrast-enhanced MRI for assessing therapeutic response of choroidal neovascularization in a rat model.

Relationship between orbital optic nerve axon counts and retinal nerve fiber layer thickness measured by spectral domain optical coherence tomography.

Metallothionein-III deficiency exacerbates light-induced retinal degeneration.

The impact of macular pigment augmentation on visual performance using different carotenoid formulations.

Ectopic epithelial implants following surface ablation of the cornea.

Short-term effects of extremely low frequency pulsed electromagnetic field on corneas with alkaline burns in rabbits.

The choroid is thicker in angle closure than in open angle and control eyes.

In vitro effects of bevacizumab treatment on newborn rat retinal cell proliferation, death, and differentiation.

Author response: Different efficacy of propranolol in mice with oxygen-induced retinopathy: could differential effects of propranolol be related to differences in mouse strains?

Year: 2012 Volume: 53 Issue: 11

Year: 2012 Volume: 53 Issue: 10

Year: 2012 Volume: 53 Issue: 9

Year: 2012 Volume: 53 Issue: 8

Year: 2012 Volume: 53 Issue: 7

Year: 2012 Volume: 53 Issue: 6

Year: 2012 Volume: 53 Issue: 5

Year: 2012 Volume: 53 Issue: 4

Year: 2012 Volume: 53 Issue: 3

Year: 2012 Volume: 53 Issue: 2

Year: 2012 Volume: 53 Issue: 1

Year: 2011 Volume: 52

Year: 2010 Volume: 51

Year: 2009 Volume: 50

Year: 2008 Volume: 49

Axonal protection via modulation of the amyloidogenic pathway in tumor necrosis factor-induced optic neuropathy.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Kojima, Kaori Kitaoka, Yasushi Munemasa, Yasunari Ueno, Satoki
Description	Country affiliation: Japan Author Affiliation: Kojima K ( Department of Ophthalmology, St Marianna University School of Medicine, Kawasaki, Kanagawa, Japan.)
Abstract	PURPOSE: To examine the changes in and localization of phosphorylated presenilin1 (p-PS1) and amyloid precursor protein (APP) in the optic nerve after intravitreal injection of TNF and to investigate the role of Î³-secretase in the cleavage of APP in optic nerve degeneration. METHODS: Groups of rats were euthanatized at 1 or 2 weeks after intravitreal injection of TNF. Levels of p-PS1 protein in the optic nerve were determined by immunoblotting and immunohistochemistry. The localization of APP was determined by immunohistochemistry, and its downstream cleavage was determined by immunoprecipitation using 6E10 antibody followed by immunoblotting with an APP intracellular domain (AICD) antibody. The effect of a Î³-secretase inhibitor on TNF-induced optic nerve degeneration was determined by counting the number of axons. RESULTS: p-PS1 was increased in the optic nerve after TNF injection and was found to colocalize with vimentin and glial fibrillary acidic protein, markers of astrocytes. Immunoprecipitation using 6E10 antibody followed by immunoblotting with AICD antibody revealed an increase in Î³-secretase activation in the optic nerve after TNF injection, which was inhibited by treatment with the Î³-secretase inhibitor. Moreover, Î³-secretase inhibition significantly prevented the loss of axons in the optic nerve after TNF injection. CONCLUSIONS: The increase in p-PS1 and activation of Î³-secretase in the optic nerve may be associated with TNF-induced axonal degeneration. Modulation of Î³-secretase activity may be useful for the treatment of TNF-related optic neuropathy.
ISSN	01460404
e-ISSN	15525783
Journal	Investigative Opthalmology & Visual Science
Issue Number	12
Volume Number	53
Language	English
Publisher	Association for Research in Vision and Ophthalmology
Publisher Date	2012-11-15
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Amyloid Beta-protein Precursor Metabolism Axons Drug Effects Optic Nerve Diseases Pathology Optic Nerve Animals Disease Models, Animal Chemically Induced Rats, Wistar Signal Transduction Tumor Necrosis Factor-alpha Adverse Effects Comparative Study Research Support, Non-u.s. Gov't Discipline Ophthalmology
Content Type	Text
Resource Type	Article
Subject	Ophthalmology Sensory Systems Cellular and Molecular Neuroscience

Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302

See location in the Map
03222 282435
Mail: support@ndl.gov.in

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in