NDLI: Automated segmentation of the choroid from clinical SD-OCT.

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Automated segmentation of the choroid from clinical SD-OCT.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Niemeijer, Meindert Sonka, Milan Abràmoff, Michael D. Lee, Kyungmoo Mullins, Robert F. Zhang, Li
Description	Country affiliation: United States Author Affiliation: Zhang L ( Department of Electrical and Computer Engineering, University of Iowa, Iowa City, Iowa, USA.)
Abstract	PURPOSE: We developed and evaluated a fully automated 3-dimensional (3D) method for segmentation of the choroidal vessels, and quantification of choroidal vasculature thickness and choriocapillaris-equivalent thickness of the macula, and evaluated repeat variability in normal subjects using standard clinically available spectral domain optical coherence tomography (SD-OCT). METHODS: A total of 24 normal subjects was imaged twice, using clinically available, 3D SD-OCT. A novel, fully-automated 3D method was used to segment and visualize the choroidal vasculature in macular scans. Local choroidal vasculature and choriocapillaris-equivalent thicknesses were determined. Reproducibility on repeat imaging was analyzed using overlapping rates, Dice coefficient, and root mean square coefficient of variation (CV) of choroidal vasculature and choriocapillaris-equivalent thicknesses. RESULTS: For the 6 × 6 mm(2) macula-centered region as depicted by the SD-OCT, average choroidal vasculature thickness in normal subjects was 172.1 µm (95% confidence interval [CI] 163.7-180.5 µm) and average choriocapillaris-equivalent thickness was 23.1 µm (95% CI 20.0-26.2 µm). Overlapping rates were 0.79 ± 0.07 and 0.75 ± 0.06, Dice coefficient was 0.78 ± 0.08, CV of choroidal vasculature thickness was 8.0% (95% CI 6.3%-9.4%), and of choriocapillaris-equivalent thickness was 27.9% (95% CI 21.0%-33.3%). CONCLUSIONS: Fully automated 3D segmentation and quantitative analysis of the choroidal vasculature and choriocapillaris-equivalent thickness demonstrated excellent reproducibility in repeat scans (CV 8.0%) and good reproducibility of choriocapillaris-equivalent thickness (CV 27.9%). Our method has the potential to improve the diagnosis and management of patients with eye diseases in which the choroid is affected.
ISSN	01460404
e-ISSN	15525783
DOI	10.1167/iovs.12-10311
Journal	Investigative Opthalmology & Visual Science
Issue Number	12
Volume Number	53
Language	English
Publisher	Association for Research in Vision and Ophthalmology
Publisher Date	2012-11-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Choroid Blood Supply Choroidal Neovascularization Diagnosis Tomography, Optical Coherence Diagnosis, Differential Reference Values Reproducibility Of Results Comparative Study Research Support, N.i.h., Extramural Research Support, U.s. Gov't, Non-p.h.s. Discipline Ophthalmology
Content Type	Text
Resource Type	Article
Subject	Ophthalmology Sensory Systems Cellular and Molecular Neuroscience

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