NDLI: Induction of Endoplasmic Reticulum Stress Genes, BiP and Chop, in Genetic and Environmental Models of Retinal Degeneration

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Dose-ranging evaluation of intravitreal siRNA PF-04523655 for diabetic macular edema (the DEGAS study).

The role of VIP in cornea.

Induction of Endoplasmic Reticulum Stress Genes, BiP and Chop, in Genetic and Environmental Models of Retinal Degeneration

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Role of hepatocyte growth factor in promoting the growth of human corneal endothelial cells stimulated by L-ascorbic acid 2-phosphate.

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Association between choroidal thickness and ocular perfusion pressure in young, healthy subjects: enhanced depth imaging optical coherence tomography study.

The IS/OS junction layer in the natural history of type 2 idiopathic macular telangiectasia.

Macular choroidal thickness measured by swept source optical coherence tomography in eyes with inferior posterior staphyloma.

Posture-induced intraocular pressure changes in eyes with open-angle glaucoma, primary angle closure with or without glaucoma medications, and control eyes.

Development-related splicing regulates pituitary adenylate cyclase-activating polypeptide (PACAP) receptors in the retina.

Keratitis-associated fungi form biofilms with reduced antifungal drug susceptibility.

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Retinal prosthesis safety: alterations in microglia morphology due to thermal damage and retinal implant contact.

Axonal protection via modulation of the amyloidogenic pathway in tumor necrosis factor-induced optic neuropathy.

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Long-term decline of central cone function in retinitis pigmentosa evaluated by focal electroretinogram.

Dynamic contrast-enhanced MRI for assessing therapeutic response of choroidal neovascularization in a rat model.

Relationship between orbital optic nerve axon counts and retinal nerve fiber layer thickness measured by spectral domain optical coherence tomography.

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The impact of macular pigment augmentation on visual performance using different carotenoid formulations.

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Short-term effects of extremely low frequency pulsed electromagnetic field on corneas with alkaline burns in rabbits.

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Author response: Different efficacy of propranolol in mice with oxygen-induced retinopathy: could differential effects of propranolol be related to differences in mouse strains?

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Induction of Endoplasmic Reticulum Stress Genes, BiP and Chop, in Genetic and Environmental Models of Retinal Degeneration

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Kroeger, Heike Gee, Jason Ahern, Kelly Messah, Carissa Matthes, Michael T. LaVail, Matthew M. Joseph, Victory Lin, Jonathan H. Yasumura, Douglas Gorbatyuk, Marina S. Chiang, Wei-Chieh
Description	Country affiliation: United States Author Affiliation: Kroeger H ( Department of Pathology, University of California, San Diego, La Jolla, California, USA.)
Abstract	PURPOSE: Endoplasmic reticulum (ER) stress has been observed in animal models of retinitis pigmentosa expressing P23H rhodopsin. We compared levels of tightly induced ER stress genes, Binding of immunoglobulin protein (BiP) and CCAAT/enhancer-binding protein homologous protein (Chop), in seven additional models of retinal degeneration arising from genetic or environmental causes. METHODS: Retinas from transgenic S334ter rhodopsin (lines 3, 4, and 5) and Royal College of Surgeons (RCS and RCS-p+) rats from postnatal (P) days 10 to 120 were analyzed. In a constant light (CL) model of retinal degeneration, BALB/c mice were exposed to 15,000 lux of CL for 0 to 8 hours. Retinal tissues from three to eight animals per experimental condition were collected for histologic and molecular analyses. RESULTS: S334ter animals revealed significant increases in BiP, S334ter-3 (3.3× at P15), S334ter-4 (4× at P60), and S334ter-5 (2.2× at P90), and Chop, S334ter-3 (1.3× at P15), S334ter-4 (1.5× at P30), and S334ter-5 (no change), compared with controls. P23H-3 rats showed significant increase of BiP at P60 (2.3×) and Chop (1.6×). RCS and RCS-p+ rats showed significant increases in BiP at P60 (2.4×) and P20 (1.8×), respectively, but no statistically significant changes in Chop. BALB/c mice showed increases in BiP (1.5×) and Chop (1.3×) after 4 hours of CL. Increased levels of these ER stress markers correlated with photoreceptor cell loss. CONCLUSIONS: Our study reveals surprising increases in BiP and to a lesser degree Chop in retinal degenerations arising from diverse causes. We propose that manipulation of ER stress responses may be helpful in treating many environmental and heritable forms of retinal degeneration.
ISSN	01460404
e-ISSN	15525783
DOI	10.1167/iovs.12-10221
Journal	Investigative Opthalmology & Visual Science
Issue Number	12
Volume Number	53
Language	English
Publisher	Association for Research in Vision and Ophthalmology
Publisher Date	2012-11-09
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Endoplasmic Reticulum Stress Genetics Gene Expression Regulation Oligopeptides Retinal Degeneration Transcription Factor Chop Animals Disease Models, Animal Electrophoresis, Polyacrylamide Gel Environmental Exposure Adverse Effects Mice Mice, Inbred Balb C Biosynthesis Photoreceptor Cells, Vertebrate Metabolism Pathology Polymerase Chain Reaction Rats, Sprague-dawley Rhodopsin Bcl-2-associated X Protein Comparative Study Research Support, N.i.h., Extramural Research Support, Non-u.s. Gov't Discipline Ophthalmology
Content Type	Text
Resource Type	Article
Subject	Ophthalmology Sensory Systems Cellular and Molecular Neuroscience

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