NDLI: Safety and efficacy of topical infliximab in a mouse model of ocular surface scarring.

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Safety and efficacy of topical infliximab in a mouse model of ocular surface scarring.

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Safety and efficacy of topical infliximab in a mouse model of ocular surface scarring.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Bignami, Fabio Franchini, Stefano Giacomini, Chiara Rama, Paolo Ferrari, Giulio
Description	Country affiliation: Italy Author Affiliation: Ferrari G ( Cornea and Ocular Surface Disease Unit, Eye Repair Lab, San Raffaele Hospital, Via Olgettina 60, Milan, Italy. ferrari.giulio@hsr.it)
Abstract	PURPOSE: To evaluate the safety/efficacy of topical infliximab, an anti-TNF- monoclonal antibody, in a mouse model of ocular surface scarring. METHODS: Twenty alkali burn mice were treated with infliximab (10 mg/mL) topically 6 times a day, while 20 alkali burn mice received saline for 7 days. Corneal opacity, epithelial wound healing, and ocular phimosis were examined at the slit-lamp. Tear production was quantified with phenol red thread test. Immunofluorescence for infliximab penetration, TNF- localization, CD45+ cell infiltration, PAS, and Masson's trichrome staining were evaluated on ocular globes and eyelids. TNF- and IL-1ß expression levels were measured on treated murine corneas and eyelids. Finally, quantification of corneal CD31+ blood vessels and LYVE1+ lymphatic vessels were evaluated on 10 additional alkali burn mice receiving either infliximab or saline, after 14 days. RESULTS: Topical infliximab penetrated the cornea and the conjunctiva and was not toxic (negative fluorescein stain). Its molecular target, TNF- , was detected in the cornea after injury. Infliximab significantly reduced corneal perforation, opacity index, phimosis, leukocyte infiltration, and fibrosis in the eyelids. It also significantly prevented goblet cell infiltration in epithelial cornea and loss in the conjunctiva (P < 0.05), improved tear secretion and epithelial healing (P < 0.05). Finally, it significantly reduced both corneal hem- (P < 0.05) and lymphangiogenesis (P < 0.01). CONCLUSIONS: Infliximab penetrates the cornea and is safe to the ocular surface in an animal model of ocular surface scarring. We suggest that topical application of infliximab may be a useful treatment in ocular caustications.
ISSN	01460404
e-ISSN	15525783
Journal	Investigative Opthalmology & Visual Science
Issue Number	3
Volume Number	54
Language	English
Publisher	Association for Research in Vision and Ophthalmology
Publisher Date	2013-03-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Anti-inflammatory Agents, Non-steroidal Pharmacology Antibodies, Monoclonal Burns, Chemical Drug Therapy Eye Burns Administration, Topical Animals Pathology Conjunctiva Cornea Metabolism Corneal Neovascularization Prevention & Control Chemically Induced Eyelids Fibrosis Goblet Cells Drug Effects Infliximab Interleukin-1beta Leukocytes Lymphangiogenesis Mice Mice, Inbred C57bl Models, Animal Random Allocation Secretion Tumor Necrosis Factor-alpha Discipline Ophthalmology
Content Type	Text
Resource Type	Article
Subject	Ophthalmology Sensory Systems Cellular and Molecular Neuroscience

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