NDLI: Temporary Sutureless Amniotic Membrane Patch for Acute Alkaline Burns

Content Provider	JAMA Network
Author	Kheirkhah, Ahmad Johnson, Daniel A. Paranjpe, Deval R. Raju, V.K. Casas, Victoria Tseng, Scheffer C. G.
Copyright Year	2008
Abstract	Objective: To evaluate the clinical outcome of a new sutureless approach for a temporary amniotic membrane patch ( Pro: Kera; Bio- Tissue, Inc, Miami, Florida) in eyes with acute burns. Methods: Retrospective review of 5 eyes of 5 patients with grades I to III acute alkaline burns, receiving Pro: Kera insertion within 8 days of injury. Results: These eyes had either total (2 cases) or extensive (60%-75%, 3 cases) corneal epithelial defects with limbal (120°-360°) and conjunctival (30%-60%) epithelial defects. Pro: Kera was inserted within a mean ( SD) of 3.7 (3.1) days after burn and repeated 1 to 3 times for 3 cases. Conjunctival defects reepithelialized in 8.2 (5) days (range, 5-17 days), while limbal and corneal defects healed in 13.6 (8.3) days (range, 5-25 days). The latter was completed with circumferential closure of limbal defects followed by centripetal healing of corneal defects. In 3 eyes, early peripheral corneal neovascularization was followed by marked regression on completion of healing. During 16.8 (10.8) months of follow-up, all eyes retained a stable surface with improved corneal clarity, and without limbal deficiency or symblepharon. Conclusion: This sutureless application of an amniotic membrane patch allows for early delivery of its biologic actions, which may help preserve remaining limbal stem cells for rapid expansion and prevent late cicatricial complications in eyes with mild and moderate acute alkaline burns.
Ending Page	1066
Starting Page	1059
Page Count	8
File Format	PDF HTM / HTML
ISSN	00039950
DOI	10.1001/archopht.126.8.1059
Issue Number	8
Journal	Archives of Ophthalmology
Volume Number	126
Language	English
Publisher	American Medical Association
Publisher Date	2008-08-11
Access Restriction	Open
Subject Keyword	amnion alkaline chemical burns epithelium symblepharon corneal epithelial defect eye florida burns follow-up cornea corneal neovascularization conjunctiva centripetal
Content Type	Text
Resource Type	Article
Subject	Ophthalmology

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