NDLI: Identification of vascular endothelial side population cells in the choroidal vessels and their potential role in age-related macular degeneration.

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Identification of vascular endothelial side population cells in the choroidal vessels and their potential role in age-related macular degeneration.

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Identification of vascular endothelial side population cells in the choroidal vessels and their potential role in age-related macular degeneration.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Wakabayashi, Taku Kidoya, Hiroyasu Naito, Hisamichi Sakimoto, Susumu Takara, Kazuhiro Nishida, Kohji Takakura, Nobuyuki Oshima, Yusuke
Description	Country affiliation: Japan Author Affiliation: Wakabayashi T ( Department of Signal Transduction, Research Institute for Microbial Diseases, Osaka University, Osaka, Japan.)
Abstract	PURPOSE: The neovascular form of age-related macular degeneration (AMD) is characterized by the growth of abnormal new blood vessels from the choroid, termed choroidal neovascularization (CNV). The origin of the new vessels in CNV, however, has not been elucidated fully to our knowledge. The purpose of this study is to identify vascular endothelial side population (SP) cells in the preexisting choroidal vessels, and investigate their potential role in AMD. METHODS: We made single cell suspensions of freshly isolated mouse choroidal, retinal, and brain tissue by enzymatic digestion. Vascular endothelial SP cells were isolated using flow cytometry based on the ability to efflux the DNA-binding dye, Hoechst 33342, via ATP-binding cassette (ABC) transporters. RESULTS: In the choroid, 2.8% of CD31â ºCD45â » vascular endothelial cells (ECs) showed a typical SP staining pattern. They were not bone marrow-derived and possessed high colony-forming capacity in vitro. They proliferated during laser-induced CNV in vivo. In contrast, stereotypic SP staining pattern was not observed in retinal and brain ECs. Retinal and brain EC-SP cells included increased SP populations with less colony-forming capacity within the SP compartment, because they contained cells with and without proliferative potential. The latter still could efflux the dye due to high levels of ABC transporters, such as ABCB1a, ABCC4, and ABCC6. CONCLUSIONS: The EC-SP cells in the choroid may represent vessel-residing endothelial stem/progenitor cells contributing mainly to angiogenesis, and may be useful for augmenting vascular regeneration or for developing new antiangiogenic therapy in AMD.
ISSN	01460404
e-ISSN	15525783
Journal	Investigative Opthalmology & Visual Science
Issue Number	10
Volume Number	54
Language	English
Publisher	Association for Research in Vision and Ophthalmology
Publisher Date	2013-10-11
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Choroid Blood Supply Endothelium, Vascular Pathology Macular Degeneration Retinal Neovascularization Atp-binding Cassette Transporters Biosynthesis Genetics Animals Cell Proliferation Metabolism Disease Models, Animal Flow Cytometry Complications Mice Mice, Inbred C57bl Real-time Polymerase Chain Reaction Etiology Comparative Study Research Support, Non-u.s. Gov't Discipline Ophthalmology
Content Type	Text
Resource Type	Article
Subject	Ophthalmology Sensory Systems Cellular and Molecular Neuroscience

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