NDLI: The age-regulating protein klotho is vital to sustain retinal function.

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The age-regulating protein klotho is vital to sustain retinal function.

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The age-regulating protein klotho is vital to sustain retinal function.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Laszczyk, Ann M. Maltare, Astha King, Gwendalyn D. Reish, Nicholas J. Gross, Alecia K. McKeown, Alex S. Kraft, Timothy W.
Description	Author Affiliation: Reish NJ ( Department of Neurobiology, University of Alabama at Birmingham, Birmingham, Alabama.)
Abstract	PURPOSE: To determine whether the age-regulating protein klotho was expressed in the retina and determine whether the absence of klotho affected retinal function. METHODS: Immunohistochemistry and qPCR of klotho knockout and wild-type mice were used to detect klotho expression in retina. Immunohistochemistry was used to probe for differences in expression of proteins important in synaptic function, retinal structure, and ionic flux. Electroretinography (ERG) was conducted on animals across lifespan to determine whether decreased klotho expression affects retinal function. RESULTS: Klotho mRNA and protein were detected in the wild-type mouse retina, with protein present in all nuclear layers. Over the short lifespan of the knockout mouse (â ¼8 weeks), no overt photoreceptor cell loss was observed, however, function was progressively impaired. At 3 weeks of age neither protein expression levels (synaptophysin and glutamic acid decarboxylase [GAD67]) nor retinal function were distinguishable from wild-type controls. However, by 7 weeks of age expression of synaptophysin, glial fibrillary acidic protein (GFAP), and transient receptor potential cation channel subfamily member 1 (TRPM1) decreased while GAD67, post synaptic density 95 (PSD95), and wheat germ agglutinin staining, representative of glycoprotein sialic acid residues, were increased relative to wild-type mice. Accompanying these changes, profound functional deficits were observed as both ERG a-wave and b-wave amplitudes compared with wild-type controls. CONCLUSIONS: Klotho is expressed in the retina and is important for healthy retinal function. Although the mechanisms for the observed abnormalities are not known, they are consistent with the accelerating aging phenotype seen in other tissues.
ISSN	01460404
e-ISSN	15525783
DOI	10.1167/iovs.13-12550
Journal	Investigative Opthalmology & Visual Science
Issue Number	10
Volume Number	54
Language	English
Publisher	Association for Research in Vision and Ophthalmology
Publisher Date	2013-10-11
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Aging Genetics Gene Expression Regulation, Developmental Glucuronidase Rna, Messenger Retina Physiology Animals Blotting, Western Disease Models, Animal Electroretinography Biosynthesis Immunohistochemistry Mice Mice, Knockout Microscopy, Fluorescence Polymerase Chain Reaction Cytology Comparative Study Research Support, N.i.h., Extramural Research Support, Non-u.s. Gov't Discipline Ophthalmology
Content Type	Text
Resource Type	Article
Subject	Ophthalmology Sensory Systems Cellular and Molecular Neuroscience

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