NDLI: In vivo lamina cribrosa micro-architecture in healthy and glaucomatous eyes as assessed by optical coherence tomography.

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In vivo lamina cribrosa micro-architecture in healthy and glaucomatous eyes as assessed by optical coherence tomography.

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In vivo lamina cribrosa micro-architecture in healthy and glaucomatous eyes as assessed by optical coherence tomography.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Sigal, Ian A. Schuman, Joel S. Kraus, Martin Lu, Chen D. Bilonick, Richard A. Grulkowski, Ireneusz Ishikawa, Hiroshi Kagemann, Larry Wang, Bo Hornegger, Joachim Nevins, Jessica E. Fujimoto, James G. Liu, Jonathan J. Nadler, Zach Wollstein, Gadi
Description	Author Affiliation: Wang B ( Department of Ophthalmology, UPMC Eye Center, Eye and Ear Institute, Ophthalmology and Visual Science Research Center, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.)
Abstract	PURPOSE: The lamina cribrosa (LC) is a prime location of glaucomatous damage. The purpose of this study was to compare LC 3-dimensional micro-architecture between healthy and glaucomatous eyes in vivo by using optical coherence tomography (OCT). METHODS: Sixty-eight eyes (19 healthy and 49 glaucomatous) from 47 subjects were scanned in a 3.5 × 3.5 × 3.64-mm volume (400 × 400 × 896 pixels) at the optic nerve head by using swept-source OCT. The LC micro-architecture parameters were measured on the visible LC by an automated segmentation algorithm. The LC parameters were compared to diagnosis and visual field mean deviation (VF MD) by using a linear mixed effects model accounting for age. RESULTS: The average VF MD for the healthy and glaucomatous eyes was -0.50 ± 0.80 dB and -7.84 ± 8.75 dB, respectively. Beam thickness to pore diameter ratio (P = 0.04) and pore diameter standard deviation (P < 0.01) were increased in glaucomatous eyes. With worse MD, beam thickness to pore diameter ratio (P < 0.01), pore diameter standard deviation (P = 0.05), and beam thickness (P < 0.01) showed a statistically significant increase while pore diameter (P = 0.02) showed a significant decrease. There were no significant interactions between any of the parameters and age (all P > 0.05). CONCLUSIONS: Glaucomatous micro-architecture changes in the LC, detected by OCT analysis, reflect beams remodeling and axonal loss leading to reduction in pore size and increased pore size variability.
ISSN	01460404
e-ISSN	15525783
DOI	10.1167/iovs.13-13109
Journal	Investigative Opthalmology & Visual Science
Issue Number	13
Volume Number	54
Language	English
Publisher	Association for Research in Vision and Ophthalmology
Publisher Date	2013-12-19
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Glaucoma, Open-angle Diagnosis Optic Disk Anatomy & Histology Pathology Optic Nerve Diseases Tomography, Optical Coherence Imaging, Three-dimensional Intraocular Pressure Nerve Fibers Retinal Ganglion Cells Vision Disorders Visual Field Tests Visual Fields Comparative Study Research Support, N.i.h., Extramural Research Support, Non-u.s. Gov't Discipline Ophthalmology
Content Type	Text
Resource Type	Article
Subject	Ophthalmology Sensory Systems Cellular and Molecular Neuroscience

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