NDLI: Is handheld optical coherence tomography reliable in infants and young children with and without nystagmus?

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Is handheld optical coherence tomography reliable in infants and young children with and without nystagmus?

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Lee, Helena Gottlob, Irene Proudlock, Frank
Description	Country affiliation: United kingdom Author Affiliation: Lee H ( Ophthalmology Group, University of Leicester, Robert Kilpatrick Clinical Sciences Building, Leicester Royal Infirmary, Leicester, United Kingdom.)
Abstract	PURPOSE: To evaluate the reliability of the spectral domain handheld OCT (HH-OCT) in assessing foveal morphology in children with and without nystagmus. METHODS: Forty-nine subjects with nystagmus (mean age 43.83 months; range, 1-82 months) and 48 controls (mean age 43.02 months; range, 0 to 83 months) were recruited and scanned using HH-OCT. A minimum of two separate volumetric scans on the same examination day of the fovea were obtained. The images were imported into ImageJ software where manual retinal layer segmentation of the central foveal B-scan was performed. Agreement between scans was assessed by determining the intraclass correlation coefficients (ICC) and Bland-Altman plots. RESULTS: Both the nystagmus and control groups showed an excellent degree of reproducibility between two examinations with ICCs greater than 0.96 for central macular thickness (CMT) and greater than 0.8 for the outer nuclear layer and outer segment of the photoreceptors. The nerve fiber layer, ganglion cell layer, outer plexiform layer, inner segment of the photoreceptors, and retinal pigment epithelium were less reliable with ICCs of less than 0.7. There was no difference in the reliability of scans obtained in children with nystagmus as compared with controls and both groups had good intereye agreement with ICCs greater than 0.94 for CMT. CONCLUSIONS: We have shown for the first time that the HH-OCT provides reliable measurements in children with and without nystagmus. This is important, as the HH-OCT will have a greater diagnostic and prognostic role in young children with nystagmus and other eye diseases in the future.
ISSN	01460404
e-ISSN	15525783
DOI	10.1167/iovs.13-13230
Journal	Investigative Opthalmology & Visual Science
Issue Number	13
Volume Number	54
Language	English
Publisher	Association for Research in Vision and Ophthalmology
Publisher Date	2013-12-17
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Algorithms Macula Lutea Pathology Nystagmus, Congenital Diagnosis Retinal Diseases Retinal Ganglion Cells Tomography, Optical Coherence Child, Preschool Diagnosis, Differential Fourier Analysis Infant Infant, Newborn Complications Reproducibility Of Results Etiology Comparative Study Research Support, Non-u.s. Gov't Discipline Ophthalmology
Content Type	Text
Resource Type	Article
Subject	Ophthalmology Sensory Systems Cellular and Molecular Neuroscience

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