NDLI: Differences in the region- and depth-dependent microstructural organization in normal versus glaucomatous human posterior sclerae.

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Differences in the region- and depth-dependent microstructural organization in normal versus glaucomatous human posterior sclerae.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Cahir, Thomas M. Yan, Dongmei Vande Geest, Jonathan P. Danford, Forest L. Dreier, Robert A. Girkin, Christopher A.
Description	Author Affiliation: Danford FL ( Department of Aerospace and Mechanical Engineering, University of Arizona, Tucson, Arizona.)
Abstract	PURPOSE: This study quantitatively investigated differences in the regional- and depth-dependent human posterior scleral microstructure in glaucomatous (G) and nonglaucomatous (NG) donors. METHODS: Twenty-five posterior poles from six G and seven NG donors were analyzed using small angle light scattering (SALS) to investigate the organization of scleral fibers around the optic nerve head. Eccentricity (Ecc), fiber splay (FS), and percent equatorial fibers (PEF) were quantified. RESULTS: Regional statistically significant differences between G and NG groups existed in Ecc (P < 0.0001), FS (P < 0.005), and PEF (P < 0.005). Distinct and substantial variation through the depth occurred in all three end points. Region-specific differences in Ecc existed at the episcleral surface; however, by 40% into the depth, all regions converged to a similar value. Fiber splay increased in all regions by an average of 0.14 from the episcleral surface to the intraocular surface. The percentage of equatorial fibers decreased universally through the depth from approximately 61% to 33%. Generally, the inferior and superior regions had a lower Ecc and PEF compared to the nasal and temporal regions. CONCLUSIONS: Region and depth of the posterior sclera are important factors that should be included when comparing scleral microstructure of G and NG tissue in experimental and computational work. The dramatic changes in the depth of the sclera may represent baseline properties that affect predisposition to primary open angle glaucoma (POAG), and necessitate that further research include depth as a factor in assessing how observed structural differences contribute to or are a result of POAG.
ISSN	01460404
e-ISSN	15525783
DOI	10.1167/iovs.13-12262
Journal	Investigative Opthalmology & Visual Science
Issue Number	13
Volume Number	54
Language	English
Publisher	Association for Research in Vision and Ophthalmology
Publisher Date	2013-12-03
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Glaucoma Pathology Intraocular Pressure Sclera Ultrastructure Biomechanical Phenomena Physiopathology Models, Theoretical Optic Disk Scattering, Small Angle Comparative Study Research Support, N.i.h., Extramural Research Support, Non-u.s. Gov't Discipline Ophthalmology
Content Type	Text
Resource Type	Article
Subject	Ophthalmology Sensory Systems Cellular and Molecular Neuroscience

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