NDLI: Imaging Glaucomatous Damage Across the Temporal Raphe.

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Imaging Glaucomatous Damage Across the Temporal Raphe.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Gast, Thomas J. Malinovsky, Victor E. Huang, Gang Swanson, William H. Luo, Ting Burns, Stephen A.
Abstract	PURPOSE: To image and analyze anatomical differences at the temporal raphe between normal and glaucomatous eyes using adaptive optics scanning laser ophthalmoscopy (AOSLO) and optical coherence tomography (OCT), and to relate these differences to visual field measurements. METHODS: Nine glaucomatous eyes of 9 patients (age 54-78 years, mean deviation of visual field [MD] -5.03 to -0.20 dB) and 10 normal eyes of 10 controls (age 54-81, MD -1.13 to +1.39 dB) were enrolled. All the participants were imaged in a region that was centered approximately 9° temporal to the fovea. The size of imaging region was at least 10° vertically by 4° horizontally. The raphe gap, defined as the distance between the superior and inferior retinal nerve fiber layer (RNFL) bundles, was measured. A bundle index was computed to quantify the relative reflectivity and density of the nerve fiber bundles. We also measured thickness of the ganglion cell complex (GCC) and RNFL. RESULTS: The raphe gap was larger in glaucomatous eyes than control eyes. Specifically, eight glaucomatous eyes with local averaged field loss no worse than -3.5 dB had larger raphe gaps than all control eyes. The bundle index, GCC thickness, and RNFL thickness were on average reduced in glaucomatous eyes, with the first two showing statistically significant differences between the two groups. CONCLUSIONS: Structural changes in the temporal raphe were observed and quantified even when local functional loss was mild. These techniques open the possibility of using the raphe as a site for glaucoma research and clinical assessment.
ISSN	01460404
e-ISSN	15525783
DOI	10.1167/iovs.15-16730
Journal	Investigative Opthalmology & Visual Science
Issue Number	6
Volume Number	56
Language	English
Publisher	Association for Research in Vision and Ophthalmology
Publisher Date	2015-06-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Glaucoma Pathology Ophthalmoscopy Tomography, Optical Coherence Case-control Studies Nerve Fibers Optic Disk Physiopathology Retinal Ganglion Cells Visual Fields Research Support, N.i.h., Extramural Discipline Ophthalmology
Content Type	Text
Resource Type	Article
Subject	Ophthalmology Sensory Systems Cellular and Molecular Neuroscience

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