NDLI: Y chromosome microdeletions in Brazilian fertility clinic patients

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Y chromosome microdeletions in Brazilian fertility clinic patients

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Y chromosome microdeletions in Brazilian fertility clinic patients

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Bordin, B. M. Amaral, W. N. Florêncio, R. S. Santos, P. R. Arruda, J. T. Rocha Filho, M. A. Approbato, M. S. Maia, M. C. Mesquita, W. E. Moura, K. K. Silva, R. C.
Spatial Coverage	Brazil
Description	Country affiliation: Brazil Responsible library: BR1.1 Author Affiliation: Arruda, J. T ( Universidade Católica de Goiás. Núcleo de Pesquisas Replicon. Goiânia. BR); Bordin, B. M ( Universidade Católica de Goiás. Núcleo de Pesquisas Replicon. Goiânia. BR); Moura, K. K ( Universidade Católica de Goiás. Núcleo de Pesquisas Replicon. Goiânia. BR); Rocha Filho, M. A ( Universidade Federal de Goiás. Hospital das Clínicas. Goiânia. BR); Amaral, W. N ( Universidade Federal de Goiás. Hospital das Clínicas. Goiânia. BR); Florêncio, R. S ( Universidade Federal de Goiás. Hospital das Clínicas. Goiânia. BR); Approbato, M. S ( Universidade Federal de Goiás. Hospital das Clínicas. Goiânia. BR); Maia, M. C ( Universidade Federal de Goiás. Hospital das Clínicas. Goiânia. BR); Silva, R. C ( Universidade Federal de Goiás. Hospital das Clínicas. Goiânia. BR); Mesquita, W. E ( Universidade Católica de Goiás. Núcleo de Pesquisas Replicon. Goiânia. BR); Santos, P. R ( Universidade Católica de Goiás. Núcleo de Pesquisas Replicon. Goiânia. BR)
Abstract	Microdeletions in Yq are associated with defects in spermatogenesis, while those in the AZF region are considered critical for germ cell development. We examined microdeletions in the Y chromosomes of patients attended at the Laboratory of Human Reproduction of the Clinical Hospital of the Federal University of Goiás as part of a screening of patients who plan to undergo assisted reproduction. Analysis was made of the AZF region of the Y chromosome in men who had altered spermograms to detect possible microdeletions in Yq. Twenty-three patients with azoospermia and 40 with severe oligozoospermia were analyzed by PCR for the detection of six sequence-tagged sites: sY84 and sY86 for AZFa, sY127 and sY134 for AZFb, and sY254 and sY255 for AZFc. Microdeletions were detected in 28 patients, including 10 azoospermics and 18 severe oligozoospermics. The patients with azoospermia had 43.4% of their microdeletions in the AZFa region, 8.6% in the AZFb region and 17.4% in the AZFc region. In the severe oligozoospermics, 40% were in the AZFa region, 5% in the AZFb region and 5% in the AZFc region. We conclude that microdeletions can be the cause of idiopathic male infertility, supporting conclusions from previous studies.
e-ISSN	16765680
Journal	Genetics and Molecular Research
Issue Number	2
Volume Number	6
Language	English
Publisher	Fundação de Pesquisas Científicas de Ribeirão Preto
Publisher Place	Brazil
Access Restriction	Open
Subject Keyword	Chromosome Deletion Chromosomes, Human, Y Ultrastructure Gene Deletion Infertility, Male Genetics Azoospermia Fertility Germ Cells Metabolism Polymerase Chain Reaction Spermatogenesis Research Support, Non-u.s. Gov't Discipline Genetics Discipline Molecular Biology Discipline Bioinformatics
Content Type	Text
Resource Type	Article

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