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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Pheanpanitporn, Yotsapoom Lin, Lung-Yi Chang, Kai-Fung Huang, Long-Sun Lai, Dar-Ming Yen, Yi-Kuang |
| Description | Author Affiliation: Huang LS ( Institute of Applied Mechanics, National Taiwan University, Taipei 106, Taiwan. Electronic address: Lshuang@ntu.edu.tw.); Pheanpanitporn Y ( Institute of Applied Mechanics, National Taiwan University, Taipei 106, Taiwan.); Yen YK ( Institute of Applied Mechanics, National Taiwan University, Taipei 106, Taiwan.); Chang KF ( Institute of Applied Mechanics, National Taiwan University, Taipei 106, Taiwan.); Lin LY ( Institute of Applied Mechanics, National Taiwan University, Taipei 106, Taiwan.); Lai DM ( Department of Surgery, National Taiwan University Hospital, Taipei 106, Taiwan.) |
| Abstract | Phenytoin, one of the most widely used antiepileptic drugs, suppresses the abnormal brain activity often seen in seizures. In this study, we report the electrical detection of phenytoin as an antiepileptic medication with a narrow therapeutic dosage range to which therapeutic drug monitoring (TDM) is applied. The measurement technique used an electrical detection of a piezoresistive microcantilever biosensor. This label-free, electrically measured microcantilever can be miniaturized in order to be portable for point-of-care, personal diagnosis or for personalized therapeutic drug monitoring. The miniaturized piezoresistive microcantilever was fabricated by micro-electro-mechanical system processes, and was integrated into a microfluidic channel with a system for label-free detection. The microcantilever biosensor was approved for the detection of phenytoin in solutions of deionized water and 100% fetal bovine serum. A linear profile in a drug-concentration range of 10-80 µg/mL was detected, with the signal resolution being about 0.005 Ω. The concentration sensitivity was 2.94×10(-6) (µg/mL)(-1). The binding affinity (KD) was calculated to be 58 µg/mL. The results of the present piezoresistive microcantilever biosensors showed a solid correlation of phenytoin drug detection with that in the clinically used fluorescence polarization immunoassay (FPIA). |
| ISSN | 09565663 |
| Volume Number | 59 |
| e-ISSN | 18734235 |
| Journal | Biosensors and Bioelectronics |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2014-09-15 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Anticonvulsants Blood Drug Monitoring Instrumentation Micro-electrical-mechanical Systems Phenytoin Animals Analysis Biosensing Techniques Cattle Equipment Design Limit Of Detection Water Evaluation Studies Journal Article Research Support, Non-u.s. Gov't Discipline Biotechnology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Nanoscience and Nanotechnology Medicine Biophysics Biomedical Engineering Biotechnology Electrochemistry |
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