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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Hwang, Tsann-Long Yen, Tzung-Hai Chiou, Chiuan-Chian Luo, Ji-Dung Purwidyantri, Agnes Yang, Chia-Ming Lin, Yi-Ting Lo, Chih-Hong Lai, Chao-Sung |
| Description | Country affiliation: Taiwan Author Affiliation: Lin YT ( Department of Electronic Engineering, Chang-Gung University, Taoyuan, Taiwan.); Purwidyantri A ( Biomedical Engineering, Chang-Gung University, Taoyuan, Taiwan.); Luo JD ( Department of Medical Biotechnology and Laboratory Science, Chang Gung University, Taoyuan, Taiwan.); Chiou CC ( Department of Medical Biotechnology and Laboratory Science, Chang Gung University, Taoyuan, Taiwan.); Yang CM ( Department of Electronic Engineering, Chang-Gung University, Taoyuan, Taiwan); Lo CH ( Department of General Surgery, Chang Gung Memorial Hospital, Linkou, Taiwan.); Hwang TL ( Department of General Surgery, Chang Gung Memorial Hospital, Linkou, Taiwan.); Yen TH ( Department of Nephrology and Division of Clinical Toxicology, Chang Gung Memorial Hospital, Linkou, Taiwan.); Lai CS ( Department of Electronic Engineering, Chang-Gung University, Taoyuan, Taiwan) |
| Abstract | A programmable field effect-based electrolyte-insulator-semiconductor (EIS) sensor constructed with a nonvolatile memory-like structure is proposed for KRAS gene DNA hybridization detection. This programmable EIS structure was fabricated with silicon oxide (SiO2)/silicon nitride (Si3N4)/silicon oxide on a p-type silicon wafer, namely electrolyte-oxide-nitride-oxide-Si (EONOS). In this research, voltage stress programming from 4 to 20V was applied to trigger holes confinement in the nitride-trapping layer that, consequently, enhances the DNA attachment onto the sensing surface due to additional electrostatic interaction. Not solely resulting from the higher DNA load, the programming may affect the orientation of the DNA that finally contributes to the change in capacitance. Findings have shown that a higher voltage program is able to increase the total capacitance and results in ~3.5- and ~5.5-times higher sensitivities for a series of concentrations for complementary DNA and wild type versus mutant DNA hybridization detection, respectively. Overall, it has been proven that the voltage program on the nonvolatile memory-like structure of EONOS is a notable candidate for genosensor development, scoping the diagnosis of a single nucleotide polymorphism (SNP)-related disease. |
| ISSN | 09565663 |
| Volume Number | 79 |
| e-ISSN | 18734235 |
| Journal | Biosensors and Bioelectronics |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2016-05-15 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Biosensing Techniques Instrumentation Polymorphism, Single Nucleotide Proto-oncogene Proteins P21(ras) Genetics Base Sequence Dna Chemistry Electric Capacitance Equipment Design Humans Immobilized Nucleic Acids Mutation Nucleic Acid Hybridization Semiconductors Silicon Compounds Silicon Dioxide Journal Article Research Support, Non-u.s. Gov't Discipline Biotechnology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Nanoscience and Nanotechnology Medicine Biophysics Biomedical Engineering Biotechnology Electrochemistry |
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