NDLI: The age lipid A2E and mitochondrial dysfunction synergistically impair phagocytosis by retinal pigment epithelial cells.

Please wait, while we are loading the content...

Year: 2017 Volume: 292

Year: 2016 Volume: 291

Year: 2015 Volume: 290

Year: 2014 Volume: 289

Year: 2013 Volume: 288

Year: 2012 Volume: 287

Year: 2011 Volume: 286

Year: 2010 Volume: 285

Year: 2009 Volume: 284

Year: 2008 Volume: 283

Year: 2008 Volume: 283 Issue: 52

Year: 2008 Volume: 283 Issue: 51

Year: 2008 Volume: 283 Issue: 50

Year: 2008 Volume: 283 Issue: 49

Year: 2008 Volume: 283 Issue: 48

Year: 2008 Volume: 283 Issue: 47

Year: 2008 Volume: 283 Issue: 46

Year: 2008 Volume: 283 Issue: 45

Year: 2008 Volume: 283 Issue: 44

Year: 2008 Volume: 283 Issue: 43

Year: 2008 Volume: 283 Issue: 42

Year: 2008 Volume: 283 Issue: 41

Year: 2008 Volume: 283 Issue: 40

Year: 2008 Volume: 283 Issue: 39

Year: 2008 Volume: 283 Issue: 38

Year: 2008 Volume: 283 Issue: 37

Year: 2008 Volume: 283 Issue: 36

Zona pellucida glycoproteins.

Tuning the strength of a bacterial N-end rule degradation signal.

Analogs of tetrahydroisoquinoline natural products that inhibit cell migration and target galectin-3 outside of its carbohydrate-binding site.

Oxidized phospholipid inhibition of toll-like receptor (TLR) signaling is restricted to TLR2 and TLR4: roles for CD14, LPS-binding protein, and MD2 as targets for specificity of inhibition.

Parcs is a dual regulator of cell proliferation and apaf-1 function.

Lactaturia and loss of sodium-dependent lactate uptake in the colon of SLC5A8-deficient mice.

The PDZ and Band 4.1 Containing Protein Frmpd1 Regulates the Subcellular Location of Activator of G-protein Signaling 3 and Its Interaction with G-proteins

Cholesterol-dependent separation of the beta2-adrenergic receptor from its partners determines signaling efficacy: insight into nanoscale organization of signal transduction.

Defective osteoclastogenesis by IKKbeta-null precursors is a result of receptor activator of NF-kappaB ligand (RANKL)-induced JNK-dependent apoptosis and impaired differentiation.

Inadequate Activation of the GTPase RhoA Contributes to the Lack of Fibronectin Matrix Assembly in von Hippel-Lindau Protein-defective Renal Cancer $Cells^{*S⃞}$

A Functionally Important Hydrogen-bonding Network at the $β_{DP}/α_{DP}$ Interface of ATP Synthase

Molecular Processes of Inhibition and Stimulation of ATP Synthase Caused by the Phytotoxin Tentoxin

The availability of surface GABA B receptors is independent of gamma-aminobutyric acid but controlled by glutamate in central neurons.

T cell receptor-mediated activation of CD4+CD44hi T cells bypasses Bcl10: an implication of differential NF-kappaB dependence of naïve and memory T cells during T cell receptor-mediated responses.

Localization of PTP-1B, SHP-2, and Src Exclusively in Rat Brain Mitochondria and Functional Consequences

PAK is regulated by PI3K, PIX, CDC42, and PP2Calpha and mediates focal adhesion turnover in the hyperosmotic stress-induced p38 pathway.

Niemann-Pick C1 Functions in Regulating Lysosomal Amine Content

A Novel Pathway of Cytochrome c Biogenesis Is Involved in the Assembly of the Cytochrome $b_{6}f$ Complex in Arabidopsis Chloroplasts

Islet Oxygen Consumption and Insulin Secretion Tightly Coupled to Calcium Derived from L-type Calcium Channels but Not from the Endoplasmic Reticulum

Processing of G4 DNA by Dna2 helicase/nuclease and replication protein A (RPA) provides insights into the mechanism of Dna2/RPA substrate recognition.

A Drosophila Model for Amyotrophic Lateral Sclerosis Reveals Motor Neuron Damage by Human $SOD1^{*♦}$

His-311 and Arg-559 are key residues involved in fatty acid oxygenation in pathogen-inducible oxygenase.

Combinatorial Signals of Activin/Nodal and Bone Morphogenic Protein Regulate the Early Lineage Segregation of Human Embryonic Stem $Cells^{*S⃞}$

Closely related members of the Medicago truncatula PHT1 phosphate transporter gene family encode phosphate transporters with distinct biochemical activities.

Multiple specificity recognition motifs enhance plant mitochondrial RNA editing in vitro.

Carbon Monoxide Inhibits L-type $Ca^{2+}$ Channels via Redox Modulation of Key Cysteine Residues by Mitochondrial Reactive Oxygen Species

The Werner syndrome protein binds replication fork and holliday junction DNAs as an oligomer.

Arginines in the first transmembrane segment promote maturation of a P-glycoprotein processing mutant by hydrogen bond interactions with tyrosines in transmembrane segment 11.

Long-chain Ceramide Is a Potent Inhibitor of the Mitochondrial Permeability Transition Pore

Structure and mechanism of GumK, a membrane-associated glucuronosyltransferase.

Palmitoylation and membrane interactions of the neuroprotective chaperone cysteine-string protein.

The Poly(ADP-ribose) Polymerase PARP-1 Is Required for Oxidative Stress-induced TRPM2 Activation in Lymphocytes

Increases in Intracellular Calcium Triggered by Channelrhodopsin-2 Potentiate the Response of Metabotropic Glutamate Receptor mGluR7

Supramolecular interactions in the dermo-epidermal junction zone: anchoring fibril-collagen VII tightly binds to banded collagen fibrils.

Bacillus subtilis RecO nucleates RecA onto SsbA-coated single-stranded DNA.

The survival-promoting peptide Y-P30 enhances binding of pleiotrophin to syndecan-2 and -3 and supports its neuritogenic activity.

ABT-737 induces expression of the death receptor 5 and sensitizes human cancer cells to TRAIL-induced apoptosis.

Defective dissociation of a 'slow' RecA mutant protein imparts an Escherichia coli growth defect.

Human AlkB homolog 1 is a mitochondrial protein that demethylates 3-methylcytosine in DNA and RNA.

Regulation of nuclear import/export of carbohydrate response element-binding protein (ChREBP): interaction of an alpha-helix of ChREBP with the 14-3-3 proteins and regulation by phosphorylation.

Nitrosylation of ISG15 prevents the disulfide bond-mediated dimerization of ISG15 and contributes to effective ISGylation.

Function and structural organization of Mot1 bound to a natural target promoter.

Cdt1 forms a complex with the minichromosome maintenance protein (MCM) and activates its helicase activity.

Vasopressin-stimulated increase in phosphorylation at Ser269 potentiates plasma membrane retention of aquaporin-2.

Retinyl ester homeostasis in the adipose differentiation-related protein-deficient retina.

Nucleoporin 88 (Nup88) is regulated by hypertonic stress in kidney cells to retain the transcription factor tonicity enhancer-binding protein (TonEBP) in the nucleus.

High Density Lipoprotein-associated Sphingosine 1-Phosphate Promotes Endothelial Barrier Function

SDF1alpha/CXCR4 signaling, via ERKs and the transcription factor Egr1, induces expression of a 67-kDa form of glutamic acid decarboxylase in embryonic hippocampal neurons.

Adenylic dinucleotides produced by CD38 are negative endogenous modulators of platelet aggregation.

Inhibitory Action of NoxA1 on Dual Oxidase Activity in Airway Cells

CGI-58, the causative gene for Chanarin-Dorfman syndrome, mediates acylation of lysophosphatidic acid.

Identification of Novel Endogenous Cytochrome P450 Arachidonate Metabolites with High Affinity for Cannabinoid Receptors

Cytosolic and plastoglobule-targeted carotenoid dioxygenases from Crocus sativus are both involved in beta-ionone release.

The proteoglycan brevican binds to fibronectin after proteolytic cleavage and promotes glioma cell motility.

Cib2 binds integrin alpha7Bbeta1D and is reduced in laminin alpha2 chain-deficient muscular dystrophy.

Complex I within Oxidatively Stressed Bovine Heart Mitochondria Is Glutathionylated on Cys-531 and Cys-704 of the 75-kDa Subunit

CCL2 Protects Prostate Cancer PC3 Cells from Autophagic Death via Phosphatidylinositol 3-Kinase/AKT-dependent Survivin Up-regulation

Inhibition of cortical neuron differentiation by Groucho/TLE1 requires interaction with WRPW, but not Eh1, repressor peptides.

15-deoxy-Delta12,14-prostaglandin J2 impairs phosphatidylcholine synthesis and induces nuclear accumulation of thiol-modified cytidylyltransferase.

Multiple cyclin kinase inhibitors promote bile acid-induced apoptosis and autophagy in primary hepatocytes via p53-CD95-dependent signaling.

On the oxygen reactivity of flavoprotein oxidases: an oxygen access tunnel and gate in brevibacterium sterolicum cholesterol oxidase.

KIF1Bbeta functions as a haploinsufficient tumor suppressor gene mapped to chromosome 1p36.2 by inducing apoptotic cell death.

Roles of STAT3/SOCS3 Pathway in Regulating the Visual Function and Ubiquitin-Proteasome-dependent Degradation of Rhodopsin during Retinal $Inflammation^{*}$

Diacylglycerol specifically blocks spontaneous integration of membrane proteins and allows detection of a factor-assisted integration.

Transforming growth factor-beta requires its target plasminogen activator inhibitor-1 for cytostatic activity.

Phosphorylation of Thr-178 and Thr-184 in the TAK1 T-loop is required for interleukin (IL)-1-mediated optimal NFkappaB and AP-1 activation as well as IL-6 gene expression.

The RING domain and first zinc finger of TRAF6 coordinate signaling by interleukin-1, lipopolysaccharide, and RANKL.

Demonstration of Short-lived Complexes of Cytochrome c with Cytochrome $bc_{1}$ by EPR Spectroscopy

Intracellular peptides as natural regulators of cell signaling.

Rad51 protein stimulates the branch migration activity of Rad54 protein.

Kruppel-like factor 5 causes cartilage degradation through transactivation of matrix metalloproteinase 9.

Functional and Structural Profiling of the Human Thrombopoietin Gene Promoter

The age lipid A2E and mitochondrial dysfunction synergistically impair phagocytosis by retinal pigment epithelial cells.

A Conformationally Mobile Cysteine Residue (Cys-561) Modulates $Na^{+}$ and $H^{+}$ Activation of Human CNT3

c-IAP1 and c-IAP2 are critical mediators of tumor necrosis factor alpha (TNFalpha)-induced NF-kappaB activation.

Acetylation of PML is involved in histone deacetylase inhibitor-mediated apoptosis.

Switching of G-protein usage by the calcium-sensing receptor reverses its effect on parathyroid hormone-related protein secretion in normal versus malignant breast cells.

Analysis of Proteinase-activated Receptor 2 and TLR4 Signal Transduction: A NOVEL PARADIGM FOR RECEPTOR COOPERATIVITY

A functional peroxisome proliferator-activated receptor-gamma ligand-binding domain is not required for adipogenesis.

The role of Kalirin9 in p75/nogo receptor-mediated RhoA activation in cerebellar granule neurons.

GABPbeta2 is dispensible for normal lymphocyte development but moderately affects B cell responses.

Modified sympathetic nerve system activity with overexpression of the voltage-dependent calcium channel beta3 subunit.

Adiponectin blocks interleukin-18-mediated endothelial cell death via APPL1-dependent AMP-activated protein kinase (AMPK) activation and IKK/NF-kappaB/PTEN suppression.

Protein kinase CK2, cystic fibrosis transmembrane conductance regulator, and the deltaF508 mutation: F508 deletion disrupts a kinase-binding site.

Year: 2008 Volume: 283 Issue: 35

Year: 2008 Volume: 283 Issue: 34

Year: 2008 Volume: 283 Issue: 33

Year: 2008 Volume: 283 Issue: 32

Year: 2008 Volume: 283 Issue: 31

Year: 2008 Volume: 283 Issue: 30

Year: 2008 Volume: 283 Issue: 29

Year: 2008 Volume: 283 Issue: 28

Year: 2008 Volume: 283 Issue: 27

Year: 2008 Volume: 283 Issue: 26

Year: 2008 Volume: 283 Issue: 25

Year: 2008 Volume: 283 Issue: 24

Year: 2008 Volume: 283 Issue: 23

Year: 2008 Volume: 283 Issue: 22

Year: 2008 Volume: 283 Issue: 21

Year: 2008 Volume: 283 Issue: 20

Year: 2008 Volume: 283 Issue: 19

Year: 2008 Volume: 283 Issue: 18

Year: 2008 Volume: 283 Issue: 17

Year: 2008 Volume: 283 Issue: 16

Year: 2008 Volume: 283 Issue: 15

Year: 2008 Volume: 283 Issue: 14

Year: 2008 Volume: 283 Issue: 13

Year: 2008 Volume: 283 Issue: 12

Year: 2008 Volume: 283 Issue: 11

Year: 2008 Volume: 283 Issue: 10

Year: 2008 Volume: 283 Issue: 9

Year: 2008 Volume: 283 Issue: 8

Year: 2008 Volume: 283 Issue: 7

Year: 2008 Volume: 283 Issue: 6

Year: 2008 Volume: 283 Issue: 5

Year: 2008 Volume: 283 Issue: 4

Year: 2008 Volume: 283 Issue: 3

Year: 2008 Volume: 283 Issue: 2

Year: 2008 Volume: 283 Issue: 1

Year: 2007 Volume: 282

Year: 2006 Volume: 281

Year: 2005 Volume: 280

Year: 2004 Volume: 279

Year: 2003 Volume: 278

Year: 2002 Volume: 277

Year: 2001 Volume: 276

Year: 2000 Volume: 275

Year: 1999 Volume: 274

Year: 1998 Volume: 273

Year: 1997 Volume: 272

Year: 1996 Volume: 271

Year: 1995 Volume: 270

Year: 1994 Volume: 269

Year: 1993 Volume: 268

Year: 1992 Volume: 267

Year: 1991 Volume: 266

Year: 1990 Volume: 265

Year: 1989 Volume: 264

Year: 1988 Volume: 263

Year: 1987 Volume: 262

Year: 1986 Volume: 261

Year: 1984 Volume: 259

Year: 1982 Volume: 257

Year: 1981 Volume: 256

Year: 1975 Volume: 250

The age lipid A2E and mitochondrial dysfunction synergistically impair phagocytosis by retinal pigment epithelial cells.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Finnemann, Silvia C. Magrane, Jordi Gao, Junping Vollmer-snarr, Heidi R. Shiraz, Ashton K. Shirazi, Arash K. Anand, Monika Manfredi, Giovanni Vives-bauza, Cristofol
Description	Author Affiliation: Vives-Bauza C ( Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York, New York 10065, USA.)
Abstract	Accumulation of indigestible lipofuscin and decreased mitochondrial energy production are characteristic age-related changes of post-mitotic retinal pigment epithelial (RPE) cells in the human eye. To test whether these two forms of age-related impairment have interdependent effects, we quantified the ATP-dependent phagocytic function of RPE cells loaded or not with the lipofuscin component A2E and inhibiting or not mitochondrial ATP synthesis either pharmacologically or genetically. We found that physiological levels of lysosomal A2E reduced mitochondrial membrane potential and inhibited oxidative phosphorylation (OXPHOS) of RPE cells. Furthermore, in media with physiological concentrations of glucose or pyruvate, A2E significantly inhibited phagocytosis. Antioxidants reversed these effects of A2E, suggesting that A2E damage is mediated by oxidative processes. Because mitochondrial mutations accumulate with aging, we generated novel genetic cellular models of RPE carrying mitochondrial DNA point mutations causing either moderate or severe mitochondrial dysfunction. Exploring these mutant RPE cells we found that, by itself, only the severe but not the moderate OXPHOS defect reduces phagocytosis. However, sub-toxic levels of lysosomal A2E are sufficient to reduce phagocytic activity of RPE with moderate OXPHOS defect and cause cell death of RPE with severe OXPHOS defect. Taken together, RPE cells rely on OXPHOS for phagocytosis when the carbon energy source is limited. Our results demonstrate that A2E accumulation exacerbates the effects of moderate mitochondrial dysfunction. They suggest that synergy of sub-toxic lysosomal and mitochondrial changes in RPE cells with age may cause RPE dysfunction that is known to contribute to human retinal diseases like age-related macular degeneration.
ISSN	00219258
e-ISSN	1083351X
Journal	Journal of Biological Chemistry
Issue Number	36
Volume Number	283
Language	English
Publisher	American Society for Biochemistry and Molecular Biology (United States)
Publisher Date	2008-09-05
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Aging Metabolism Lipofuscin Mitochondria Phagocytosis Pigment Epithelium Of Eye Pyridinium Compounds Retinoids Adenosine Triphosphate Genetics Pathology Animals Antioxidants Pharmacology Cell Death Drug Effects Cell Line DNA, Mitochondrial Epithelial Cells Glucose Lysosomes Macular Degeneration Membrane Potential, Mitochondrial Mitosis Oxidative Phosphorylation Point Mutation Pyruvic Acid Rats, Long-Evans Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Biochemistry Molecular Biology
Content Type	Text
Resource Type	Article
Subject	Cell Biology Biochemistry Molecular Biology

Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302

See location in the Map
03222 282435
Mail: support@ndl.gov.in

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in