NDLI: Cib2 binds integrin alpha7Bbeta1D and is reduced in laminin alpha2 chain-deficient muscular dystrophy.

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Cib2 binds integrin alpha7Bbeta1D and is reduced in laminin alpha2 chain-deficient muscular dystrophy.

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Cib2 binds integrin alpha7Bbeta1D and is reduced in laminin alpha2 chain-deficient muscular dystrophy.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Meszaros, Renata Akerlund, Mikael Durbeej, Madeleine Bigotti, Maria Giulia Brancaccio, Andrea Häger, Mattias Carmignac, Virginie Holmberg, Johan Mayer, Ulrike Allamand, Valérie Kalamajski, Sebastian
Description	Author Affiliation: Häger M ( Department of Experimental Medical Science, Division for Cell and Matrix Biology, University of Lund, 221 84 Lund, Sweden.)
Abstract	Mutations in the gene encoding laminin alpha2 chain cause congenital muscular dystrophy type 1A. In skeletal muscle, laminin alpha2 chain binds at least two receptor complexes: the dystrophin-glycoprotein complex and integrin alpha7beta1. To gain insight into the molecular mechanisms underlying this disorder, we performed gene expression profiling of laminin alpha2 chain-deficient mouse limb muscle. One of the down-regulated genes encodes a protein called Cib2 (calcium- and integrin-binding protein 2) whose expression and function is unknown. However, the closely related Cib1 has been reported to bind integrin alphaIIb and may be involved in outside-in-signaling in platelets. Since Cib2 might be a novel integrin alpha7beta1-binding protein in muscle, we have studied Cib2 expression in the developing and adult mouse. Cib2 mRNA is mainly expressed in the developing central nervous system and in developing and adult skeletal muscle. In skeletal muscle, Cib2 colocalizes with the integrin alpha7B subunit at the sarcolemma and at the neuromuscular and myotendinous junctions. Finally, we demonstrate that Cib2 is a calcium-binding protein that interacts with integrin alpha7Bbeta1D. Thus, our data suggest a role for Cib2 as a cytoplasmic effector of integrin alpha7Bbeta1D signaling in skeletal muscle.
ISSN	00219258
e-ISSN	1083351X
Journal	Journal of Biological Chemistry
Issue Number	36
Volume Number	283
Language	English
Publisher	American Society for Biochemistry and Molecular Biology (United States)
Publisher Date	2008-09-05
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Calcium-Binding Proteins Metabolism Central Nervous System Embryology Integrins Laminin Genetics Muscle, Skeletal Muscular Dystrophy, Animal Animals Gene Expression Profiling Gene Expression Regulation, Developmental Mice Mice, Mutant Strains Neuromuscular Junction Oxidation-Reduction Platelet Membrane Glycoprotein IIb Protein Binding Sarcolemma Signal Transduction Research Support, Non-U.S. Gov't Biochemistry Molecular Biology
Content Type	Text
Resource Type	Article
Subject	Cell Biology Biochemistry Molecular Biology

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