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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Vazquez, Silvia N. Landázuri, Manuel O. Méndez, Fernando Feijóo-cuaresma, Monica Naranjo-suarez, Salvador Castellanos, Maria C. Esteban, Miguel A. Del Cerro, Mercedes Hernández García-pardo, Angeles Calzada, Maria J. Maqueda, Alfredo |
| Description | Author Affiliation: Feijóo-Cuaresma M ( Servicio de Inmunología, Hospital de la Princesa, Departamento de Medicina, Universidad Autónoma de Madrid, Diego de León 62, 28006 Madrid, Spain.) |
| Abstract | The von Hippel-Lindau (VHL) tumor suppressor gene regulates extracellular matrix deposition. In VHL negative renal cancer cells, VHL(-), the lack of fibronectin matrix assembly is thought to promote and maintain tumor angiogenesis allowing vessels to infiltrate tumors. Therefore, and considering the importance of this process in tumor growth, we aimed to study why VHL(-) renal cancer cells fail to form a proper extracellular matrix. Our results showed that VHL(-) cells were not defective in fibronectin production and that the fibronectin produced by these cells was equally functional in promoting cell adhesion and matrix assembly as that produced by VHL(+) cells. We have previously reported that VHL(-) cells fail to form β1 integrin fibrillar adhesions and have a diminished organization of actin stress fibers; therefore, we aimed to study if the small GTPase family is involved in this process. We found that activation of the RhoA GTPase was defective in VHL(-) cells, and this was possibly mediated by an increased activation of its inhibitor, p190RhoGAP. Additionally, the expression of constitutively active RhoA in VHL(-) cells resulted in formation of a fibronectin matrix. These results strongly suggest an important role for RhoA in some of the defects observed in renal cancer cells. |
| ISSN | 00219258 |
| e-ISSN | 1083351X |
| Journal | Journal of Biological Chemistry |
| Issue Number | 36 |
| Volume Number | 283 |
| Language | English |
| Publisher | American Society for Biochemistry and Molecular Biology (United States) |
| Publisher Date | 2008-09-05 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Extracellular Matrix Metabolism Fibronectins Biosynthesis Kidney Neoplasms Enzymology Neovascularization, Pathologic Von Hippel-Lindau Tumor Suppressor Protein RhoA GTP-Binding Protein Antigens, CD29 Genetics Cell Adhesion Cell Line, Tumor Enzyme Activation Pathology GTPase-Activating Proteins Stress Fibers Antagonists & Inhibitors Research Support, Non-U.S. Gov't Biochemistry Molecular Biology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Biochemistry Molecular Biology |
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