NDLI: The availability of surface GABA B receptors is independent of gamma-aminobutyric acid but controlled by glutamate in central neurons.

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The availability of surface GABA B receptors is independent of gamma-aminobutyric acid but controlled by glutamate in central neurons.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Terunuma, Miho Vargas, Karina J. Couve, Andrés Tello, Judith A. Moss, Stephen J. Pangalos, Menelas N.
Description	Author Affiliation: Vargas KJ ( Fisiología y Biofísica, Instituto de Ciencias Biomédicas, Facultad de Medicina, Universidad de Chile, Independencia 1027, Santiago, Chile.)
Abstract	The efficacy of synaptic transmission depends on the availability of ionotropic and metabotropic neurotransmitter receptors at the plasma membrane, but the contribution of the endocytic and recycling pathways in the regulation of gamma-aminobutyric acid type B (GABA(B)) receptors remains controversial. To understand the mechanisms that regulate the abundance of GABA(B) receptors, we have studied their turnover combining surface biotin labeling and a microscopic immunoendocytosis assay in hippocampal and cortical neurons. We report that internalization of GABA(B) receptors is agonist-independent. We also demonstrate that receptors endocytose in the cell body and dendrites but not in axons. Additionally, we show that GABA(B) receptors endocytose as heterodimers via clathrin- and dynamin-1-dependent mechanisms and that they recycle to the plasma membrane after endocytosis. More importantly, we show that glutamate decreases the levels of cell surface receptors in a manner dependent on an intact proteasome pathway. These observations indicate that glutamate and not GABA controls the abundance of surface GABA(B) receptors in central neurons, consistent with their enrichment at glutamatergic synapses.
ISSN	00219258
e-ISSN	1083351X
Journal	Journal of Biological Chemistry
Issue Number	36
Volume Number	283
Language	English
Publisher	American Society for Biochemistry and Molecular Biology (United States)
Publisher Date	2008-09-05
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Cerebral Cortex Metabolism Glutamic Acid Hippocampus Neurons Receptors, GABA-B Synaptic Transmission Physiology Gamma-Aminobutyric Acid Animals Cell Membrane Cytology Clathrin Dynamin I Endocytosis Pregnancy Proteasome Endopeptidase Complex Rats, Sprague-Dawley Synapses Research Support, Non-U.S. Gov't Biochemistry Molecular Biology
Content Type	Text
Resource Type	Article
Subject	Cell Biology Biochemistry Molecular Biology

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