NDLI: Zinc can play chaperone-like and inhibitor roles during import of mitochondrial small Tim proteins.

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Zinc can play chaperone-like and inhibitor roles during import of mitochondrial small Tim proteins.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Yan, Guanhua Ang, Swee Kim Lu, Hui Morgan, Bruce
Description	Author Affiliation: Morgan B ( Faculty of Life Sciences, The University of Manchester, Michael Smith Building, Oxford Road, Manchester M13 9PT, United Kingdom.)
Abstract	Zinc is an essential cofactor required for the function of approximately 8% of the yeast and 10% of the human proteome. All of the 'small Tim' proteins of the mitochondrial intermembrane space contain a strictly conserved 'twin CX(3)C' zinc finger motif, which can bind zinc ions in the Cys-reduced form. We have shown previously that although disulfide bond formation is essential for the function of these proteins in mitochondria, only reduced proteins can be imported into mitochondria (Lu, H., Allen, S., Wardleworth, L., Savory, P., and Tokatlidis, K. (2004) J. Biol. Chem. 279, 18952-18958 and Morgan, B., and Lu, H. (2008) Biochem. J. 411, 115-122). However, the role of zinc during the import of these proteins is unclear. This study shows that the function of zinc is complex. It can play a thiol stabilizer role preventing oxidative folding of the small Tim proteins and maintaining the proteins in an import-competent form. On the other hand, zinc-bound forms cannot be imported into mitochondria efficiently. Furthermore, our results show that zinc is a powerful inhibitor of Erv1, an essential component of the import pathway used by the small Tim proteins. We propose that zinc plays a chaperone-like role in the cytosol during biogenesis of the small Tim proteins and that the proteins are imported into mitochondria through the apo-forms.
ISSN	00219258
e-ISSN	1083351X
Journal	Journal of Biological Chemistry
Issue Number	11
Volume Number	284
Language	English
Publisher	American Society for Biochemistry and Molecular Biology (United States)
Publisher Date	2009-03-13
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Membrane Proteins Metabolism Membrane Transport Proteins Mitochondria Mitochondrial Proteins Molecular Chaperones Saccharomyces Cerevisiae Proteins Saccharomyces Cerevisiae Zinc Genetics Mitochondrial Membrane Transport Proteins Antagonists & Inhibitors Pharmacology Oxidation-Reduction Drug Effects Oxidoreductases Acting On Sulfur Group Donors Protein Folding Protein Transport Physiology Research Support, Non-U.S. Gov't Biochemistry Molecular Biology
Content Type	Text
Resource Type	Article
Subject	Cell Biology Biochemistry Molecular Biology

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