NDLI: Calcium Signaling in Brain Mitochondria: INTERPLAY OF MALATE ASPARTATE NADH SHUTTLE AND CALCIUM UNIPORTER/MITOCHONDRIAL DEHYDROGENASE PATHWAYS

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Calcium Signaling in Brain Mitochondria: INTERPLAY OF MALATE ASPARTATE NADH SHUTTLE AND CALCIUM UNIPORTER/MITOCHONDRIAL DEHYDROGENASE PATHWAYS

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Contreras, Laura Satrústegui, Jorgina
Description	Author Affiliation: Contreras L ( Departamento de Biología Molecular, Centro de Biología Molecular Severo Ochoa, Universidad Autónoma de Madrid-CSIC and CIBER de Enfermedades Raras, 28049 Madrid, Spain.)
Abstract	Ca2+ signaling in mitochondria has been mainly attributed to Ca2+ entry to the matrix through the Ca2+ uniporter and activation of mitochondrial matrix dehydrogenases. However, mitochondria can also sense increases in cytosolic Ca2+ through a mechanism that involves the aspartate-glutamate carriers, extramitochondrial Ca2+ activation of the NADH malate-aspartate shuttle (MAS). Both pathways are linked through the shared substrate alpha-ketoglutarate (alphaKG). Here we have studied the interplay between the two pathways under conditions of Ca2+ activation. We show that alphaKG becomes limiting when Ca2+ enters in brain or heart mitochondria, but not liver mitochondria, resulting in a drop in alphaKG efflux through the oxoglutarate carrier and in a drop in MAS activity. Inhibition of alphaKG efflux and MAS activity by matrix Ca2+ in brain mitochondria was fully reversible upon Ca2+ efflux. Because of their differences in cytosolic calcium concentration requirements, the MAS and Ca2+ uniporter-mitochondrial dehydrogenase pathways are probably sequentially activated during a Ca2+ transient, and the inhibition of MAS at the center of the transient may provide an explanation for part of the increase in lactate observed in the stimulated brain in vivo.
ISSN	00219258
e-ISSN	1083351X
Journal	Journal of Biological Chemistry
Issue Number	11
Volume Number	284
Language	English
Publisher	American Society for Biochemistry and Molecular Biology (United States)
Publisher Date	2009-03-13
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Aspartic Acid Metabolism Brain Calcium Channels Calcium Signaling Physiology Malates Mitochondria, Heart Mitochondrial Proteins NAD Organic Anion Transporters Animals Calcium Cytosol Ketoglutaric Acids Mice Research Support, Non-U.S. Gov't Biochemistry Molecular Biology
Content Type	Text
Resource Type	Article
Subject	Cell Biology Biochemistry Molecular Biology

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