NDLI: Roles of Tom70 in import of presequence-containing mitochondrial proteins.

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Roles of Tom70 in import of presequence-containing mitochondrial proteins.

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Roles of Tom70 in import of presequence-containing mitochondrial proteins.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Shiota, Takuya Terao, Kayoko Fukui, Kenji Yoshihisa, Tohru Nishikawa, Shuh-ichi Takahashi, Hisashi Uchida, Mayumi Yamano, Koji Kitamura, Shingo Esaki, Masatoshi Yamamoto, Hayashi Endo, Toshiya
Description	Author Affiliation: Yamamoto H ( Department of Chemistry, Graduate School of Science, Japan Science and Technology Agency, Research Centre for Material Science, Nagoya University, Chikusa-ku, Nagoya 464-8602, Japan.)
Abstract	Mitochondrial protein traffic requires precise recognition of the mitochondrial targeting signals by the import receptors on the mitochondrial surface including a general import receptor Tom20 and a receptor for presequence-less proteins, Tom70. Here we took a proteome-wide approach of mitochondrial protein import in vitro to find a set of presequence-containing precursor proteins for recognition by Tom70. The presequences of the Tom70-dependent precursor proteins were recognized by Tom20, whereas their mature parts exhibited Tom70-dependent import when attached to the presequence of Tom70-independent precursor proteins. The mature parts of the Tom70-dependent precursor proteins have the propensity to aggregate, and the presence of the receptor domain of Tom70 prevents their aggregate formation. Therefore Tom70 plays the role of a docking site for not only cytosolic chaperones but also aggregate-prone substrates to maintain their solubility for efficient transfer to downstream components of the mitochondrial import machineries.
ISSN	00219258
e-ISSN	1083351X
Journal	Journal of Biological Chemistry
Issue Number	46
Volume Number	284
Language	English
Publisher	American Society for Biochemistry and Molecular Biology (United States)
Publisher Date	2009-11-13
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Mitochondria Metabolism Mitochondrial Membrane Transport Proteins Mitochondrial Proteins Protein Precursors Proteome Saccharomyces Cerevisiae Proteins Saccharomyces Cerevisiae Electrophoresis, Gel, Two-Dimensional Genetics Molecular Chaperones RNA, Fungal Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization Research Support, Non-U.S. Gov't Biochemistry Molecular Biology
Content Type	Text
Resource Type	Article
Subject	Cell Biology Biochemistry Molecular Biology

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