NDLI: Insulin-secreting cells from human eyelid-derived stem cells alleviate type I diabetes in immunocompetent mice.

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Insulin-secreting cells from human eyelid-derived stem cells alleviate type I diabetes in immunocompetent mice.

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Insulin-secreting cells from human eyelid-derived stem cells alleviate type I diabetes in immunocompetent mice.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Kang, Hyun Mi Kim, Jiyoung Park, Seah Kim, Jinyoung Kim, Haekwon Kim, Kyung Sik Lee, Eun Jig Seo, Sung Ig Kang, Sung Goo Lee, Jong-Eun Lim, Hyunjung
Description	Author Affiliation: Kang HM ( Department of Biotechnology, Seoul Women's University, Seoul, Korea.)
Abstract	Various attempts have been made to develop stem cell-based therapy to alleviate type I diabetes using animal models. However, it has been a question whether human insulin produced from explanted cells is solely responsible for the normoglycemia of diabetic animals. In this study, we isolated neural crest-like stem cells from the human eyelid fat and examined their therapeutic potentials for diabetes. The human eyelid adipose-derived stem cells (HEACs) displayed characteristics of neural crest cells. Using a two-step culture condition combined with nicotinamide, activin, and/or GLP-1, we differentiated HEACs into insulin-secreting cells and examined in vivo effects of differentiated cells by transplantation experiments. Following differentiation in vitro, HEACs released insulin and c-peptide in a glucose-dependent manner. Upon their transplantation under kidney capsules of streptozotocin-treated immunocompetent mice, we observed normalization of hyperglycemia in 10 of 20 recipient mice until sacrifice after 2 months. Only the human, but not the mouse, insulin and c-peptide were detected in the blood of recipient mice. Removal of the kidneys transplanted with HEACs resulted in a sharp increase of blood glucose level. Removed kidney tissues showed distinct expression of various human genes including insulin, and colocalization of the human insulin and the human nuclear protein in many cells. However, they showed diminished or null expression of some immune-related genes. In conclusion, human insulin alone produced from eyelid-derived stem cells following differentiation into insulin-secreting cells and transplantation could normalize type I diabetes in mice.
File Format	HTM / HTML
ISSN	10665099
Issue Number	8
Volume Number	27
e-ISSN	15494918
Journal	STEM CELLS
Language	English
Publisher	Wiley
Publisher Date	2009-08-01
Publisher Place	United States
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Cell Biology Discipline Embryology Adipose Tissue Cytology Diabetes Mellitus, Type 1 Surgery Insulin-secreting Cells Transplantation Insulin Secretion Stem Cells Adolescent Adult Aged Animals Cell Differentiation Cells, Cultured Child Diabetes Mellitus, Experimental Blood Eyelids Humans Metabolism Drug Effects Mice Middle Aged Stem Cell Transplantation Methods Physiology Young Adult Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Cell Biology Developmental Biology Medicine Molecular Medicine

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