NDLI: Ligands and oxidants in ferrihemochrome formation and oxidative hemolysis.

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Ligands and oxidants in ferrihemochrome formation and oxidative hemolysis.

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Ligands and oxidants in ferrihemochrome formation and oxidative hemolysis.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Itano, H. A. Vedvick, T. S. Hirota, K.
Abstract	We have investigated the effect of size of a single neutral ring substituent on the induction of hemolytic anemia and the formation of a ferrihemochrome by substituted phenylhydrazines. The severity of induced anemia decreased with increase in size of a halogen atom or an alkyl group ortho to the hydrazino group, little anemia resulting from 2-iodophenylhydrazine and no anemia from 2-tert-butylphenylhydrazine. The size of a halogen atom or an alkyl group at the meta or para position had relatively little effect on the severity of induced anemia. The ability of an arylhydrazine to induce hemolytic anemia paralleled its ability to produce a ferrihemochrome with an exogenous ligand, probably the corresponding aryldiazene. In general, rapid and complete formation of ferrihemochrome occurred with arylhydrazines that induced severe anemia. The degree of hemolysis induced by an arylhydrazine was not related to its rate of autooxidation, i.e., the rate at which oxidants are formed by the reduction of oxygen. We propose a mechanism of arylhydrazine-induced oxidative denaturation based on the simultaneous formation of hydroxyl radical and aryldiazene ferrihemochrome in a reaction of oxyhemoglobin with arylhydrazine. We suggest that after oxidation of the porphyrin ring is initiated by a hydroxyl radical, oxidative cleavage of the ring is facilitated by the presence of a large ligand in the heme crevice. Thus, aryldiazene ferrihemochrome may contribute to instability in a hemoglobin molecule, whereas globin ferrihemochrome results from instability.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	6
Volume Number	74
Language	English
Publisher	National Academy of Sciences
Publisher Date	1977-09-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Anemia, Hemolytic Blood Methemoglobin Metabolism Chemically Induced Animals Blood Cell Count Hematocrit Kinetics Ligands Oxidation-Reduction Oxygen Phenylhydrazines Protein Binding Rabbits Reticulocytes Physiology Spectrophotometry Structure-Activity Relationship Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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