NDLI: Pregrowth hormone messenger RNA: glucocorticoid induction and identification in rat pituitary cells.

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Pregrowth hormone messenger RNA: glucocorticoid induction and identification in rat pituitary cells.

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Pregrowth hormone messenger RNA: glucocorticoid induction and identification in rat pituitary cells.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Tushinski, R. J. Bancroft, F. C. Sussman, P. M. Yu, L. Y.
Abstract	We have investigated whether the large (5- to 15-fold) stimulation of synthesis of growth hormone (somatotropin) observed upon exposure of a strain of rat pituitary (GH3) cells to dexamethasone (a synthetic glucocorticoid) arises from a stimulation of pregrowth hormone mRNA. A good agreement was observed between the stimulation of growth hormone synthesis and the stimulation of cytoplasmic levels of pregrowth hormone mRNA, assayed by translation in wheat germ extracts. Electrophoresis on formamide-acrylamide gels of oligo(dT)-treated membrane fraction RNA revealed a band that was induced by dexamethasone to about the same extent as was translatable pregrowth hormone mRNA. Elution of the band and translation in wheat germ extracts showed directly that it contained pregrowth hormone mRNA. These results suggest that the dexamethasone induction of growth hormone synthesis in GH3 cells arises from an accumulation of pregrowth hormone mRNA in the cytoplasm of the cells. The pregrowth hormone mRNA band observed by gel electrophoresis had an estimated molecular weight of 3.6 X 10(5), suggesting the existence in this molecule of an untranslated region at least 200 nucleotides in length.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	6
Volume Number	74
Language	English
Publisher	National Academy of Sciences
Publisher Date	1977-09-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Dexamethasone Pharmacology Growth Hormone Biosynthesis Protein Biosynthesis Drug Effects RNA, Messenger Metabolism Cell Line Molecular Weight Pituitary Neoplasms Plants Isolation & Purification Triticum Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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