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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Mcmillan, C. Cline, S. Snyder, M. Bradley, D. Yarus, M. |
| Abstract | By using sites for the restriction nuclease Hpa II, the information for the anticodon stem and loop of an altered Su+2 amber suppressor tRNA (a mutant of tRNAGln) has been transplanted to a specially prepared tRNATrp gene, which lacks it homologous anticodon stem and loop sequence. The resulting tRNA gene was cloned under lac operator-promoter control. The result is a functional, hybrid, amber-suppressor tRNA that can exhibit a moderately high efficiency in translation. It appears less efficient, however, than Su+7 tRNA, the amber suppressor that results from a direct anticodon mutation in tRNATrp. As judged by its suppressor spectrum, which is almost identical to the spectra of Su+2, and Su+7, the recomposed tRNA inserts glutamine at amber sites. This experiment is the prototype of a series of construction that examine the role of the nucleotides in the anticodon region. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 9 |
| Volume Number | 77 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 1980-01-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | RNA, Transfer Biosynthesis Anticodon Bacteriophage Lambda Cloning, Molecular DNA Restriction Enzymes Escherichia Coli Genetics Genes Genes, Synthetic Genetic Vectors Ligases Plasmids Recombination, Genetic Suppression, Genetic Transformation, Genetic Research Support, U.S. Gov't, P.H.S. Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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