Syngeneic tumor cells can induce alloreactive T killer cells: a biological role for transplantation antigens.

Content Provider	Semantic Scholar
Author	Schirrmacher, Volker Hübsch, D. Garrido, F.
Copyright Year	1980
Abstract	A chemically induced sarcoma of BALB/c (H-2d) mice, MCG4, is shown to induce in BALB/c lymphocytes a primary anti-tumor cytolytic T lymphocyte (CTL) reaction in vitro. The anti-tumor CTL showed tumor specificity but reacted also with normal cells expressing distinct H-2 alloantigens. The CTL response could be shown to be induced by and directed against alloantigenic determinants expressed on two different molecules, one H-2Kk-like the other H-2Dk-like. The biological significance of these findings is discussed with regard to (i) possibility of derepression of normally silent H-2 genes in tumor cells and normal cells, (ii) generation of alloreactivity in ontogeny, and (iii) role of alloreactive T cells in eliminating cells expressing wrong gH-2 antigens.
File Format	PDF HTM / HTML
DOI	10.1073/pnas.77.9.5409
PubMed reference number	6449011
Journal	Medline
Volume Number	77
Issue Number	9
Alternate Webpage(s)	http://www.pnas.org/content/77/9/5409.full.pdf
Alternate Webpage(s)	https://doi.org/10.1073/pnas.77.9.5409
Journal	Proceedings of the National Academy of Sciences of the United States of America
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article