NDLI: Active site and complete sequence of the suicidal methyltransferase that counters alkylation mutagenesis.

Please wait, while we are loading the content...

Year: 2017 Volume: 114

Year: 2016 Volume: 113

Year: 2015 Volume: 112

Year: 2014 Volume: 111

Year: 2013 Volume: 110

Year: 2012 Volume: 109

Year: 2011 Volume: 108

Year: 2010 Volume: 107

Year: 2009 Volume: 106

Year: 2008 Volume: 105

Year: 2007 Volume: 104

Year: 2006 Volume: 103

Year: 2005 Volume: 102

Year: 2004 Volume: 101

Year: 2003 Volume: 100

Year: 2002 Volume: 99

Year: 2001 Volume: 98

Year: 2000 Volume: 97

Year: 1999 Volume: 96

Year: 1998 Volume: 95

Year: 1997 Volume: 94

Year: 1996 Volume: 93

Year: 1995 Volume: 92

Year: 1994 Volume: 91

Year: 1993 Volume: 90

Year: 1992 Volume: 89

Year: 1991 Volume: 88

Year: 1990 Volume: 87

Year: 1989 Volume: 86

Year: 1988 Volume: 85

Year: 1987 Volume: 84

Year: 1986 Volume: 83

Year: 1985 Volume: 82

Year: 1985 Volume: 82 Issue: 24

Year: 1985 Volume: 82 Issue: 23

Year: 1985 Volume: 82 Issue: 22

Year: 1985 Volume: 82 Issue: 21

Year: 1985 Volume: 82 Issue: 20

Year: 1985 Volume: 82 Issue: 19

Year: 1985 Volume: 82 Issue: 18

Year: 1985 Volume: 82 Issue: 17

Year: 1985 Volume: 82 Issue: 16

Year: 1985 Volume: 82 Issue: 15

Year: 1985 Volume: 82 Issue: 14

Year: 1985 Volume: 82 Issue: 13

Year: 1985 Volume: 82 Issue: 12

Year: 1985 Volume: 82 Issue: 11

Year: 1985 Volume: 82 Issue: 10

Year: 1985 Volume: 82 Issue: 9

Developmental and hormonal regulation of alpha 2u-globulin gene transcription.

Dissection of Mycobacterium tuberculosis antigens using recombinant DNA.

gamma-Fluoromethotrexate: synthesis and biological activity of a potent inhibitor of dihydrofolate reductase with greatly diminished ability to form poly-gamma-glutamates.

The 140-kDa adenovirus DNA polymerase is recognized by antibodies to Escherichia coli-synthesized determinants predicted from an open reading frame on the adenovirus genome.

Purification of the platelet-derived growth factor receptor by using an anti-phosphotyrosine antibody.

Nucleotide sequence of a yeast Ty element: evidence for an unusual mechanism of gene expression.

Evidence that polymorphism in the murine major histocompatibility complex may be generated by the assortment of subgene sequences.

Involvement of I-J epitopes in the self- and allo-recognition sites of T cells: blocking of syngeneic and allogeneic mixed lymphocyte reaction-responder cells by monoclonal anti-I-J antibodies.

A molecular basis for the Ia.2 and Ia.19 antigenic determinants.

Amelioration of lytic abnormalities of paroxysmal nocturnal hemoglobinuria with decay-accelerating factor.

5-Azacytidine and sodium butyrate induce expression of aromatase in fibroblasts from chickens carrying the henny feathering trait but not from wild-type chickens.

Hybrid molecules containing the B-domain of insulin-like growth factor I are recognized by carrier proteins of the growth factor.

Two distinct Ca-dependent K currents in bullfrog sympathetic ganglion cells.

Phorbol esters induce transient internalization without degradation of unoccupied epidermal growth factor receptors.

Isolation of a cDNA clone for the liver cell adhesion molecule (L-CAM).

Structure of a human histone cDNA: evidence that basally expressed histone genes have intervening sequences and encode polyadenylylated mRNAs.

Deletions near the albino locus on chromosome 7 of the mouse affect the level of tyrosine aminotransferase mRNA.

Intraterminal injection of synapsin I or calcium/calmodulin-dependent protein kinase II alters neurotransmitter release at the squid giant synapse.

Sequence-specific recognition of B-DNA by oligo(N-methylpyrrolecarboxamide)s.

Direct measurement of the electrogenic activity of o-type cytochrome oxidase from Escherichia coli reconstituted into planar lipid bilayers.

Differential regulation of bovine brain calmodulin-dependent cyclic nucleotide phosphodiesterase isoenzymes by cyclic AMP-dependent protein kinase and calmodulin-dependent phosphatase.

Sequence variation in the gene for the immunogenic capsid protein VP1 of foot-and-mouth disease virus type A.

1,2-Diacylglycerol and phorbol ester inhibit agonist-induced formation of inositol phosphates in human platelets: possible implications for negative feedback regulation of inositol phospholipid hydrolysis.

Primary structure and gene organization of human hepatitis A virus.

Identification of pTiC58 plasmid-encoded proteins for virulence in Agrobacterium tumefaciens.

Cloning of Physarum actin sequences in an exonuclease-deficient bacterial host.

Molecular cloning of a full-length cDNA for human alcohol dehydrogenase.

Nucleotide sequence of two overlapping myc-related genes in avian carcinoma virus OK10 and their relation to the myc genes of other viruses and the cell.

Poliovirus protease does not mediate cleavage of the 220,000-Da component of the cap binding protein complex.

Modification of pK values caused by change in H-bond geometry.

Generation of leukotrienes by human monocytes upon stimulation of their beta-glucan receptor during phagocytosis.

Avian myelocytomatosis virus immortalizes differentiated quail chondrocytes.

Purification of hemopoietin 1: a multilineage hemopoietic growth factor.

Platelet-derived collagenase inhibitor: characterization and subcellular localization.

Evolution of mouse major histocompatibility complex genes borne by t chromosomes.

The telomeric region of the human X chromosome long arm: presence of a highly polymorphic DNA marker and analysis of recombination frequency.

A drug-resistant mutation in the ribosomal DNA of Tetrahymena.

Insertion of long interspersed repeated elements at the Igh (immunoglobulin heavy chain) and Mlvi-2 (Moloney leukemia virus integration 2) loci of rats.

Restriction fragment length polymorphism of the human c-fms gene.

Insertion of an unstable element in an intervening sequence of maize Adh1 affects transcription but not processing.

Nucleotide sequence preservation of human mitochondrial DNA.

Predicted protein sequence of the murine I-E-beta S-polypeptide chain from cDNA and genomic clones.

Cloning and expression of the Rickettsia prowazekii ADP/ATP translocator in Escherichia coli.

Isolation and characterization of an olfactory receptor protein for odorant pyrazines.

A mechanism for memory storage insensitive to molecular turnover: a bistable autophosphorylating kinase.

Characterization of the spo0A locus and its deduced product.

Pertussis toxin inhibits fMet-Leu-Phe- but not phorbol ester-stimulated changes in rabbit neutrophils: role of G proteins in excitation response coupling.

Propagation of some human DNA sequences in bacteriophage lambda vectors requires mutant Escherichia coli hosts.

D-Tryptophan-6 analog of luteinizing hormone-releasing hormone as a protective agent against testicular damage caused by cyclophosphamide in baboons.

Polyclonal antibodies to phospholipid/Ca2+-dependent protein kinase and immunocytochemical localization of the enzyme in rat brain.

Identification and characterization of the human type II collagen gene (COL2A1).

Effect of regional DNA methylation on gene expression.

Replication initiator protein of plasmid R6K autoregulates its own synthesis at the transcriptional step.

P1 plasmid replication: multiple functions of RepA protein at the origin.

Type IX collagen from sternal cartilage of chicken embryo contains covalently bound glycosaminoglycans.

Antifreeze protein genes are tandemly linked and clustered in the genome of the winter flounder.

Isolation of stable preinitiation, initiation, and elongation complexes from RNA polymerase II-directed transcription.

Pertussis toxin inhibition of chemotaxis and the ADP-ribosylation of a membrane protein in a human-mouse hybrid cell line.

Differential scanning calorimetry of nuclei reveals the loss of major structural features in chromatin by brief nuclease treatment.

Detection in extracts of bovine brain of lipophilic complexes of sulfate esters of cholesterol and beta-sitosterol.

Initiation of transcription from each of the two human mitochondrial promoters requires unique nucleotides at the transcriptional start sites.

Growth-dependent expression of multiple species of DNA methyltransferase in murine erythroleukemia cells.

Scavenger receptor-mediated recognition of maleyl bovine plasma albumin and the demaleylated protein in human monocyte macrophages.

Purification of a vitamin K epoxide reductase that catalyzes conversion of vitamin K 2,3-epoxide to 3-hydroxy-2-methyl-3-phytyl-2,3-dihydronaphthoquinone.

19-Hydroxylation of androgens in the rat brain.

Mutations in the phosphoglucose isomerase gene can lead to marked alterations in cellular ATP levels in cultured fibroblasts exposed to simple nutrient shifts.

A monoclonal antibody disrupting calcium-dependent cell-cell adhesion of brain tissues: possible role of its target antigen in animal pattern formation.

Ontogeny of hamster hemoglobins in yolk-sac erythroid cells in vivo and in culture.

Morphogenetic rearrangement of injected collagen in developing chicken limb buds.

Silkmoth chorion gene families contain patchwork patterns of sequence homology.

Plasmid-induced 'hit-and-run' tumorigenesis in Chinese hamster embryo fibroblast (CHEF) cells.

Evidence for a prevalent dimorphism in the activation peptide of human coagulation factor IX.

Lack of evidence for skeletal abnormalities in offspring of mice exposed to ethylnitrosourea.

Intron-mediated recombination may cause a deletion in an alpha 1 type I collagen chain in a lethal form of osteogenesis imperfecta.

mRNA precursor splicing in vivo: sequence requirements determined by deletion analysis of an intervening sequence.

The translocated c-myc oncogene of Raji Burkitt lymphoma cells is not expressed in human lymphoblastoid cells.

Complete primary structures of two major murine serum amyloid A proteins deduced from cDNA sequences.

Assignment of the gene coding for the T3-delta subunit of the T3-T-cell receptor complex to the long arm of human chromosome 11 and to mouse chromosome 9.

Specificity analysis of mouse monoclonal antibodies defining cell surface antigens of human renal cancer.

Increased activity of the glucose cycle in the liver: early characteristic of type 2 diabetes.

O6-Alkylguanine-DNA alkyltransferase activity correlates with the therapeutic response of human rhabdomyosarcoma xenografts to 1-(2-chloroethyl)-3-(trans-4-methylcyclohexyl)-1-nitrosourea.

An initiator of carcinogenesis selectively and stably inhibits stem cell differentiation: a concept that initiation of carcinogenesis involves multiple phases.

Essential role of phospholipase A2 activity in endothelial cell-induced modification of low density lipoprotein.

Natural history of restricted synthesis and expression of measles virus genes in subacute sclerosing panencephalitis.

Dopamine decreases conductance of the electrical junctions between cultured retinal horizontal cells.

Fucose-containing glycolipids are stage- and region-specific antigens in developing embryonic brain of rodents.

Rearrangement of T-cell receptor beta-chain genes during T-cell development.

B-cell stimulatory factor 1 activates resting B cells.

A chemically cleavable biotinylated nucleotide: usefulness in the recovery of protein-DNA complexes from avidin affinity columns.

Consensus sequence for Escherichia coli heat shock gene promoters.

Active site and complete sequence of the suicidal methyltransferase that counters alkylation mutagenesis.

Incorporation of cellular and plasma fibronectins into smooth muscle cell extracellular matrix in vitro.

Susceptibility of human malaria parasites to chloroquine is pH dependent.

Molecular analysis of an EL4 cell line that expresses H-2Db but not H-2Kb or beta 2-microglobulin.

Retraction: Prolactin induces release of a factor from membranes capable of stimulating beta-casein gene transcription in isolated mammary cell nuclei.

Nucleotide sequences of the sporulation gene spo0A and its mutant genes of Bacillus subtilis.

Nucleotide sequence and organization of the mouse adenine phosphoribosyltransferase gene: presence of a coding region common to animal and bacterial phosphoribosyltransferases that has a variable intron/exon arrangement.

Preferential binding of benzo[a]pyrene diol epoxide to the linker DNA of human foreskin fibroblasts in S phase in the presence of benzamide.

'Exon-shuffling' maps control of antibody- and T-cell-recognition sites to the NH2-terminal domain of the class II major histocompatibility polypeptide A beta.

Antigen-binding specificities of antibodies are primarily determined by seven residues of VH.

In vitro studies of 2,4-dihydroxyphenylalanine, a prodrug targeted against malignant melanoma cells.

Levels of human and rat hypothalamic growth hormone-releasing factor as determined by specific radioimmunoassay systems.

Distribution of UDPglucuronosyltransferase in rat tissue.

Year: 1985 Volume: 82 Issue: 8

Year: 1985 Volume: 82 Issue: 7

Year: 1985 Volume: 82 Issue: 6

Year: 1985 Volume: 82 Issue: 5

Year: 1985 Volume: 82 Issue: 4

Year: 1985 Volume: 82 Issue: 3

Year: 1985 Volume: 82 Issue: 2

Year: 1985 Volume: 82 Issue: 1

Year: 1984 Volume: 81

Year: 1983 Volume: 80

Year: 1982 Volume: 79

Year: 1981 Volume: 78

Year: 1980 Volume: 77

Year: 1979 Volume: 76

Year: 1978 Volume: 75

Year: 1977 Volume: 74

Year: 1976 Volume: 73

Year: 1975 Volume: 72

Year: 1974 Volume: 71

Year: 1973 Volume: 70

Year: 1972 Volume: 69

Year: 1971 Volume: 68

Year: 1970 Volume: 67

Year: 1970 Volume: 66

Year: 1970 Volume: 65

Year: 1969 Volume: 64

Year: 1969 Volume: 63

Year: 1969 Volume: 62

Year: 1968 Volume: 61

Year: 1968 Volume: 60

Year: 1968 Volume: 59

Year: 1967 Volume: 58

Year: 1967 Volume: 57

Year: 1966 Volume: 56

Year: 1966 Volume: 55

Active site and complete sequence of the suicidal methyltransferase that counters alkylation mutagenesis.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Sedgwick, B. Robins, P. Waterfield, M. D. Totty, N. Lindahl, T. Demple, B.
Abstract	The inducible resistance to alkylation mutagenesis and killing in Escherichia coli (the adaptive response) is controlled by the ada gene. The Ada protein acts both as a positive regulator of the response and as a DNA repair enzyme, correcting premutagenic O6-alkylguanine in DNA by suicidal transfer of the alkyl group to one of its own cysteine residues. We have determined the DNA sequence of the cloned ada+ gene and its regulatory region. The data reveal potential sites of ada autoregulation. Amino acid sequence determinations show that the active center for the O6-methylguanine-DNA methyltransferase is located close to the polypeptide COOH terminus and has the unusual sequence -Pro-Cys-His-, preceded by a very hydrophobic region. These same structural features are present at the active site of thymidylate synthase, suggesting a common chemical mechanism for activation of the cysteine.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	9
Volume Number	82
Language	English
Publisher	National Academy of Sciences
Publisher Date	1985-06-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Escherichia Coli Metabolism Methyltransferases Mutation Alkylation Amino Acid Sequence Binding Sites DNA Repair Genetics Genes, Bacterial O(6)-Methylguanine-DNA Methyltransferase Operon Thymidylate Synthase Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302

See location in the Map
03222 282435
Mail: support@ndl.gov.in

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in