NDLI: Effect of regional DNA methylation on gene expression.

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Developmental and hormonal regulation of alpha 2u-globulin gene transcription.

Dissection of Mycobacterium tuberculosis antigens using recombinant DNA.

gamma-Fluoromethotrexate: synthesis and biological activity of a potent inhibitor of dihydrofolate reductase with greatly diminished ability to form poly-gamma-glutamates.

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Purification of the platelet-derived growth factor receptor by using an anti-phosphotyrosine antibody.

Nucleotide sequence of a yeast Ty element: evidence for an unusual mechanism of gene expression.

Evidence that polymorphism in the murine major histocompatibility complex may be generated by the assortment of subgene sequences.

Involvement of I-J epitopes in the self- and allo-recognition sites of T cells: blocking of syngeneic and allogeneic mixed lymphocyte reaction-responder cells by monoclonal anti-I-J antibodies.

A molecular basis for the Ia.2 and Ia.19 antigenic determinants.

Amelioration of lytic abnormalities of paroxysmal nocturnal hemoglobinuria with decay-accelerating factor.

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Phorbol esters induce transient internalization without degradation of unoccupied epidermal growth factor receptors.

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Identification of pTiC58 plasmid-encoded proteins for virulence in Agrobacterium tumefaciens.

Cloning of Physarum actin sequences in an exonuclease-deficient bacterial host.

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Effect of regional DNA methylation on gene expression.

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Effect of regional DNA methylation on gene expression.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Keshet, I. Yisraeli, J. Cedar, H.
Abstract	The effect of DNA methylation on the transcriptional activity of the hamster adenine phosphoribosyltransferase (aprt) and the herpes thymidine kinase (tk) genes has been investigated. By using M13 constructs containing these gene sequences, specific segments of each gene were methylated in vitro by restriction fragment primer-directed second-strand synthesis using the substrate 2'-deoxy-5-methyl-cytidine triphosphate (dmCTP). These hybrid-methylated molecules were inserted into mouse Ltk- cells by DNA-mediated cotransfer. In all cases, the integrated sequences retained the in vitro-directed methylation pattern. The aprt gene was inhibited by CpG methylation in the 5' region but was unaffected by methylation at the 3' end or in adjacent M13 sequences. In contrast to this, DNA methylation in both the 5' promoter region and the 3' structural region of the tk gene had a strong inhibitory effect. This suggests that this modification may affect transcription by mechanisms that do not involve the direct alteration of recognition sequences for RNA polymerase.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	9
Volume Number	82
Language	English
Publisher	National Academy of Sciences
Publisher Date	1985-06-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	DNA Genetics Gene Expression Regulation Adenine Phosphoribosyltransferase Animals Cloning, Molecular Cricetinae Metabolism Genes Herpesviridae Methylation Mice Operon Thymidine Kinase Transcription, Genetic Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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