NDLI: A drug-resistant mutation in the ribosomal DNA of Tetrahymena.

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A drug-resistant mutation in the ribosomal DNA of Tetrahymena.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Martin, L. Blackburn, E. H. Bruns, P. J. Katzen, A. L.
Abstract	A mutation that confers resistance to the drug paromomycin is shown to be in the structural gene that codes for the ribosomal RNA in Tetrahymena. This observation was made by exploiting a variant of the ribosomal DNA that distorts amplification of this locus when a new somatic nucleus develops during conjugation. Because the allelic forms of this locus have a restriction endonuclease site polymorphism, it was possible to correlate drug resistance with presence of a specific allele. The genetic results have been confirmed by sequence analysis (presented elsewhere). Thus, the crosses presented here provide a unique opportunity to identify mutations in the ribosomal DNA.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	9
Volume Number	82
Language	English
Publisher	National Academy of Sciences
Publisher Date	1985-06-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	DNA, Ribosomal Genetics Tetrahymena Alleles Animals DNA Restriction Enzymes Drug Resistance, Microbial Gene Amplification Genes Mutation Paromomycin Pharmacology Drug Effects Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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