NDLI: Human striatal dopamine receptors are organized in compartments.

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Human striatal dopamine receptors are organized in compartments.

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Human striatal dopamine receptors are organized in compartments.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Marshall, J. F. Sapp, D. W. Joyce, J. N.
Abstract	Dopamine (D2) receptors visualized in postmortem human striatum by quantitative autoradiography of [3H]spiroperidol binding are organized into circumscribed zones of low receptor density separated from other such zones by regions of higher D2 density. The D2-rich zones of the caudate nucleus and putamen contain twice the binding of D2-poor zones. The Hill coefficient, obtained from saturation analysis of [3H]spiroperidol binding to thin sections of human striatum, gave a value near unity, indicating the binding was occurring to a single type of site. The patchiness of [3H]spiroperidol binding was unaltered by postincubation removal of lipid from the tissue sections, indicating that a differential absorption of tritium in white and grey matter does not account for the heterogeneous distribution. The D2-rich and D2-poor regions appear to form labyrinths oriented in the anterior-posterior axis and are typically aligned with, respectively, acetylcholinesterase-rich and -poor compartments as visualized on stained adjacent sections. Thus, the distribution of dopamine D2 receptors conforms to the 'striosomal' organization of the human caudate-putamen, a finding that suggests that this receptor subtype may mediate the influence of dopamine on distinct neurochemical compartments within the structure.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	20
Volume Number	83
Language	English
Publisher	National Academy of Sciences
Publisher Date	1986-11-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Corpus Striatum Receptors, Dopamine Acetylcholinesterase Autoradiography Receptors, Dopamine D2 Spiperone Metabolism Tritium Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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