NDLI: Engineering of the mRNA-interfering complementary RNA immune system against viral infection.

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Developmental and tissue-specific regulation of the Q10 class I gene by DNA methylation.

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Computer analysis of retroviral pol genes: assignment of enzymatic functions to specific sequences and homologies with nonviral enzymes.

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Engineering of the mRNA-interfering complementary RNA immune system against viral infection.

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Differential effects of transforming growth factor type beta on the growth and function of adrenocortical cells in vitro.

Codon insertion mutants of the adenovirus terminal protein.

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Transformation of a human poliovirus receptor gene into mouse cells.

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Localization and comparative nucleotide sequence analysis of the transforming domain in herpes simplex virus DNA containing repetitive genetic elements.

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Molecular cloning and characterization of cDNA encoding the GTP-binding protein alpha i and identification of a related protein, alpha h.

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Complete amino acid sequence of human thyroxine-binding globulin deduced from cloned DNA: close homology to the serine antiproteases.

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Physical association of the human base-excision repair enzyme uracil DNA glycosylase with the 70,000-dalton catalytic subunit of DNA polymerase alpha.

Nuclear magnetic resonance study of the globular domain of chicken histone H5: resonance assignment and secondary structure.

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Importance of a hydrophobic residue in binding and catalysis by dihydrofolate reductase.

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Random-clone strategy for genomic restriction mapping in yeast.

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Small deletions of the short arm of the Y chromosome in 46,XY females.

Identification of the 5'-flanking regulatory region responsible for the difference in transcriptional control between mouse complement C4 and Slp genes.

Inherited polymorphism of the human T-cell antigen receptor detected by a monoclonal antibody.

Distinct human leukemia-associated cell surface glycoprotein GP160 defined by monoclonal antibody SN6.

Rapid degradation restricts measles virus matrix protein expression in a subacute sclerosing panencephalitis cell line.

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Absence of antibodies to the human immunodeficiency virus in sera from Africa prior to 1975.

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Oral immunization and protection of raccoons (Procyon lotor) with a vaccinia-rabies glycoprotein recombinant virus vaccine.

Transforming gene in human atherosclerotic plaque DNA.

Evolutionary progression at synaptic connections made by identified homologous neurones.

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Isolation of components due to intracortical processing in the visual evoked potential.

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Regulation of expression of genes for light-harvesting antenna proteins LH-I and LH-II; reaction center polypeptides RC-L, RC-M, and RC-H; and enzymes of bacteriochlorophyll and carotenoid biosynthesis in Rhodobacter capsulatus by light and oxygen.

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Engineering of the mRNA-interfering complementary RNA immune system against viral infection.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Inokuchi, Y. Hirashima, A. Sawaki, S. Inouye, M.
Abstract	Creation of an artificial mRNA-interfering complementary RNA (micRNA) immune system, utilizing anti-sense RNAs to inhibit viral gene expression, has been shown to be an effective way to prevent viral infection. In the RNA coliphage SP, the gene for the maturation protein was found to be the best target for this type of immune system; mRNA-interfering complementary RNAs specific to the genes for coat protein and replicase were less effective in preventing infection. The greatest inhibitory effect was observed with a 240-base sequence encompassing the 24-base noncoding region of the maturation gene plus the 216-base coding sequence. Significantly, even a 19-base sequence covering only the Shine-Dalgarno sequence (ribosome-binding region) without the coding region exerted a strong inhibitory effect on phage proliferation. In contrast to the highly specific action against phage SP exhibited by the longer mRNA-interfering complementary RNA, the specificity with the shorter mRNA-interfering complementary RNA was broadened to phages Q beta and GA as well as SP, all of which are classified in the different groups of RNA coliphages. Therefore, this type of anti-viral reagent may be designed to have a particular breadth of specificity, thus increasing its value in various research and possibly clinical applications.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	20
Volume Number	83
Language	English
Publisher	National Academy of Sciences
Publisher Date	1986-11-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Coliphages Genetics Genes, Viral RNA Immunology Virus Diseases DNA Plasmids RNA, Complementary Structure-Activity Relationship Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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