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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Sandmeier, H. Iida, S. Meyer, J. Hiestand-nauer, R. Arber, W. |
| Description | Author Affiliation: Sandmeier H ( Abteilung Mikrobiologie, Biozentrum der Universität Basel, Switzerland.); |
| Abstract | Plasmid p15B of Escherichia coli 15T- carries a 3.5-kilobase segment that undergoes frequent DNA inversion mediated by the DNA inversion enzyme Min, a member of the Din family of site-specific recombinases. While the previously described Din inversion systems invert a DNA segment between two crossover sites in inverted orientation, the Min system produces more complex DNA rearrangements. These have been physically characterized by electron microscopy and by restriction cleavage analysis. The results can best be explained by a model that involves six crossover sites (called mix) and predicts 240 isomeric forms of the invertible region. The model was confirmed by sequencing the six mix sites in plasmids that contain the invertible DNA segments in a frozen configuration. All mix sites fit the dix consensus sequence, and they are all good substrates for DNA inversion when carried in inverted orientation. Recombination between two mix sites in direct orientation was rare, in line with the notion that Din inversion systems are topologically biased to the inversion reaction. Another recently described multiple inversion system, the shufflon of the E. coli plasmid R64, is neither functionally nor structurally related to the Min system of p15B. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 3 |
| Volume Number | 87 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 1990-03-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Chromosome Inversion DNA Nucleotidyltransferases Metabolism DNA, Bacterial Genetics Escherichia Coli Plasmids Recombination, Genetic Chromosome Deletion Ultrastructure Enzymology Genes, Bacterial Microscopy, Electron Restriction Mapping Research Support, Non-U.S. Gov't Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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