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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Haag-weber, M. Hörl, W. H. Georgopoulos, A. Block, L. H. |
| Description | Author Affiliation: Hörl WH ( Department of Medicine, University of Freiburg, Federal Republic of Germany.); |
| Abstract | A granulocyte inhibitory protein was isolated and characterized from uremic serum by using ion-exchange column chromatography, high-performance size-exclusion chromatography, and immunochemical procedures. The purification process concentrated the protein 240-fold and to a purity of greater than 95%. An overall recovery of 45% was achieved; the purified protein had a specific activity of 104 units per mg of protein. The polypeptide had a molecular weight of approximately 28,000 and an isoelectric point of 4.0-4.5. Amino acid sequencing of the NH2 terminus revealed a single sequence (Asp-Ile-Val-Met-Thr-Gln-Ser-Pro-Gly-Thr-Leu-Ser-Val-Ser-Pro-Gly-Glu-Arg-Ala- Thr) that proved to be nonhomologous with other serum proteins that appear during an inflammatory state. The polypeptide inhibited the uptake of deoxyglucose, chemotaxis, oxidative metabolism, and intracellular bacterial killing by polymorphonuclear leukocytes. A specific rabbit polyclonal antibody raised against the protein nullified these inhibitory changes. We contend that the protein is responsible for the leukocyte dysfunction that is commonly seen in patients with uremia. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 16 |
| Volume Number | 87 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 1990-09-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Chemotaxis, Leukocyte Kidney Failure, Chronic Urine Neutrophils Drug Effects Peptides Isolation & Purification Proteinuria Uremia Amino Acid Sequence Chromatography, High Pressure Liquid Chromatography, Ion Exchange Enzyme-Linked Immunosorbent Assay Immune Sera Molecular Sequence Data N-Formylmethionine Leucyl-Phenylalanine Pharmacology Physiology Reference Values Sequence Homology, Nucleic Acid Ultrafiltration Comparative Study Research Support, Non-U.S. Gov't Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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