NDLI: Positive selection of transgenic receptor-bearing thymocytes by Kb antigen is altered by Kb mutations that involve peptide binding.

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Positive selection of transgenic receptor-bearing thymocytes by Kb antigen is altered by Kb mutations that involve peptide binding.

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Positive selection of transgenic receptor-bearing thymocytes by Kb antigen is altered by Kb mutations that involve peptide binding.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Pease, L. R. Newberry, R. D. Loh, D. Y. Nelson, C. A. Pullen, J. K. Sha, W. C. Russell, J. H.
Description	Author Affiliation: Sha WC ( Howard Hughes Medical Institute, Department of Medicine, Washington University School of Medicine, Saint Louis, MO 63110.);
Abstract	A specific interaction between the class I major histocompatibility complex molecule Kb and thymocytes expressing the antigen receptor from the cytolytic T lymphocyte 2C enhances maturation of T cells of the CD8 lineage in transgenic mice. By analyzing transgenic mice backcrossed to Kbm mutant strains of mice, we have identified five bm mutations of the Kb antigen-encoding gene that alter the positive selection of thymocytes induced by Kb antigen. Compared with Kb, Kbm10 and Kbm1 did not induce significant maturation of 2C T-cell receptor-bearing thymocytes, and Kbm8 antigen positively selected for transgenic thymocytes only weakly. Altering residue 77 of Kb molecule from aspartic acid to serine made Kbm3 and Kbm11 allogeneic targets for the 2C antigen receptor and caused deletion of transgenic thymocytes. This deletion spared T cells that expressed low levels of CD8, a result differing from the total deletion of CD8-bearing T cells seen in mice that expressed the original target alloantigen Ld. This evidence indicates that (i) self-peptides bound to thymic major histocompatibility complex molecules can influence the positive selection of thymocytes and (ii) thymocytes with apparently weak interaction with self-major histocompatibility complex antigens can escape clonal deletion.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	16
Volume Number	87
Language	English
Publisher	National Academy of Sciences
Publisher Date	1990-09-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Antigens, Bacterial Antigens, Surface Genetics Histocompatibility Antigens Class I Receptors, Antigen, T-Cell T-Lymphocytes Immunology Animals Antigens, CD8 Antigens, Differentiation, T-Lymphocyte Cytotoxicity, Immunologic DNA Replication Flow Cytometry Lymphocyte Activation Mice Mice, Transgenic Mutation Phenotype Polymerase Chain Reaction Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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