NDLI: Chronic myeloproliferative disease induced by site-specific integration of Abelson murine leukemia virus-infected hemopoietic stem cells.

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Chronic myeloproliferative disease induced by site-specific integration of Abelson murine leukemia virus-infected hemopoietic stem cells.

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Chronic myeloproliferative disease induced by site-specific integration of Abelson murine leukemia virus-infected hemopoietic stem cells.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Wong, P. M. Han, X. D. Chung, S. W.
Description	Author Affiliation: Han XD ( Morse Institute of Molecular Genetics, Department of Microbiology and Immunology, State University of New York Health Science Center, Brooklyn 11203.);
Abstract	We recently showed that hemopoietic stem cells expressing the v-abl oncogene can cause leukemia when injected into lethally irradiated recipient mice. Progenitor cells expressing v-abl did not significantly contribute to disease development, and the leukemia was monoclonal in origin. By serially transplanting v-abl-transduced hemopoietic stem cells into normal, nonirradiated syngeneic recipients, we showed that multiple stem-cell clones do exist in some recipients. These cells fluctuated as normal stem cells do and could home to normal bone marrow. Based on the time course of disease, the recipients developed either an acute or a chronic phase of disorder. All recipients with the acute disease had stem-cell clones with random Abelson murine leukemia virus integration sites. All recipients with the chronic disorder had a specific Abelson murine leukemia virus integration site. We believe this abl-specific integration site, termed ASI, is important in abl-mediated stem-cell leukemogenesis.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	22
Volume Number	88
Language	English
Publisher	National Academy of Sciences
Publisher Date	1991-12-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Abelson Murine Leukemia Virus Genetics Hematopoietic Stem Cells Microbiology Leukemia, Experimental Myeloproliferative Disorders Isolation & Purification Pathogenicity Animals Blotting, Southern DNA, Viral Genes, Abl Hematopoietic Stem Cell Transplantation Liver Embryology Mice Mice, Inbred BALB C Restriction Mapping Whole-Body Irradiation Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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