NDLI: Differential effects of Bcl-2 on T and B cells in transgenic mice.

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Differential effects of Bcl-2 on T and B cells in transgenic mice.

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Differential effects of Bcl-2 on T and B cells in transgenic mice.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Siegel, R. M. Katsumata, M. Reed, J. C. Tsujimoto, Y. Nowell, P. C. Greene, M. I. Miyashita, T. Louie, D. C.
Description	Author Affiliation: Katsumata M ( Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia 19104-6082.);
Abstract	We have produced bcl-2 transgenic mice by using a construct which mimics the t(14;18) translocation in human follicular lymphomas. Although lymphoid tissues from all transgenic mice contained high levels of human Bcl-2 protein, transgene expression was differentially regulated within the B- and T-cell compartments of lines derived from various founder mice. We have characterized the phenotypes of two lines of bcl-2 transgenic mice (line 2 and line 6) in which bcl-2 transgene expression was restricted primarily to the T- or B-cell lineages, respectively. Analysis of line 6 lymphocytes revealed a polyclonal expansion of B cells, and these B cells exhibited prolonged survival in vitro. In line 2 mice, numbers of T cells in the peripheral lymphoid tissues were more moderately elevated despite enhanced T-cell survival in vitro. Line 2 transgenic mice also showed significantly increased proportions of thymocytes with a mature phenotype. Taken together, these findings suggest different roles for bcl-2 in the in vivo regulation of B- and T-cell development and homeostasis.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	23
Volume Number	89
Language	English
Publisher	National Academy of Sciences
Publisher Date	1992-01-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	B-Lymphocytes Cytology Proto-Oncogene Proteins Genetics T-Lymphocytes Animals Physiology Cell Survival Gene Expression Hematopoiesis Lymph Nodes Mice Mice, Transgenic Proto-Oncogene Proteins C-bcl-2 Spleen Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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