NDLI: cAMP modulates multiple K+ currents, increasing spike duration and excitability in Aplysia sensory neurons.

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cAMP modulates multiple K+ currents, increasing spike duration and excitability in Aplysia sensory neurons.

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cAMP modulates multiple K+ currents, increasing spike duration and excitability in Aplysia sensory neurons.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Abrams, T. W. Goldsmith, B. A.
Description	Author Affiliation: Goldsmith BA ( Department of Biology, University of Pennsylvania, Philadelphia 19104.);
Abstract	Enhancement of the defensive withdrawal reflex of Aplysia involves a prolongation of the action potentials of mechanosensory neurons, which contributes to facilitation of transmitter release from these cells. Recent reports have suggested that whereas cAMP-dependent modulation of K+ current increases sensory neuron excitability, a cAMP-independent decrease in K+ current may increase the action potential duration and, thus, facilitate transmitter release. We have tested this proposal using Walsh cAMP-dependent protein kinase inhibitor or activators of the cAMP cascade and found that cAMP plays a major role in the spike-broadening effects of facilitatory transmitter; however, broadening requires higher levels of activation of the cAMP-dependent kinase than does increasing excitability. A steeply voltage-dependent transient K+ current, termed IKV,early, and the slowly activating S-type K+ (S-K+) current are both reduced by activation of the cAMP cascade, although with different sensitivities to the second messenger, enabling excitability and spike duration to be regulated independently. Differences in cAMP sensitivity also suggested that the originally described S-K+ current actually consists of two independent components, a slowly activating component and a time-independent, 'steady-state' current that is activated at rest.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	23
Volume Number	89
Language	English
Publisher	National Academy of Sciences
Publisher Date	1992-01-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Aplysia Physiology Cyclic AMP Neurons, Afferent Potassium Channels Potassium Protein Kinases Action Potentials Drug Effects Adenine Analogs & Derivatives Pharmacology Animals Cyproheptadine Electric Conductivity Enzyme Activation In Vitro Techniques Ion Channel Gating Protein Kinase Inhibitors Receptors, Serotonin Serotonin Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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