NDLI: Positive supercoiling of DNA greatly diminishes mRNA synthesis in yeast.

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Positive supercoiling of DNA greatly diminishes mRNA synthesis in yeast.

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Positive supercoiling of DNA greatly diminishes mRNA synthesis in yeast.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Wang, J. C. Gartenberg, M. R.
Description	Author Affiliation: Gartenberg MR ( Department of Biochemistry and Molecular Biology, Harvard University, Cambridge, MA 02138.);
Abstract	In Saccharomyces cerevisiae cells harboring a GAL1 promoter-linked beta-galactosidase gene, the simultaneous expression of Escherichia coli DNA topoisomerase I and inactivation of yeast DNA topoisomerases I and II reduces the cellular level of beta-galactosidase to an undetectable level. Analysis of intracellular mRNA level and the density of RNA polymerase along DNA indicates that this reduction is due to the suppression of transcription and that both plasmid-borne and chromosomally located genes are affected. These results are interpreted in terms of inhibition of transcription in vivo due to positive supercoiling of the DNA template: preferential removal of transcription-generated negative supercoils by E. coli DNA topoisomerase I in the absence of both yeast DNA topoisomerases I and II results in the accumulation of positive supercoils in intracellular DNA. In normal prokaryotic or eukaryotic cells, accumulation of positive supercoils is presumably avoided through the balanced actions of DNA topoisomerases.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	23
Volume Number	89
Language	English
Publisher	National Academy of Sciences
Publisher Date	1992-01-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	DNA Topoisomerases, Type I Metabolism DNA, Superhelical Genetics RNA, Messenger Transcription, Genetic DNA, Fungal Genes, Fungal Molecular Sequence Data Nucleic Acid Conformation Oligodeoxyribonucleotides Chemistry Plasmids Saccharomyces Cerevisiae Templates, Genetic Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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