NDLI: Specific prolongation of allograft survival by a T-cell-receptor-derived peptide.

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Specific prolongation of allograft survival by a T-cell-receptor-derived peptide.

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Specific prolongation of allograft survival by a T-cell-receptor-derived peptide.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Alexander-miller, M. A. Flye, M. W. Connolly, J. M. Goss, J. A. Gorka, J. Hansen, T. H.
Description	Author Affiliation: Goss JA ( Department of Surgery, Washington University School of Medicine, St. Louis, MO 63110.);
Abstract	Allograft rejection results from the specific recognition by host CD8+ T cells of allogeneic major histocompatibility complex (MHC) molecules on the tissue graft. The specificity of this cellular response is determined by the molecular interaction of the T-cell receptor (TCR) on host T cells with the MHC molecule and its bound ligand on the grafted tissue. To better understand the precise manner by which the TCR interacts with the MHC-peptide complex and how to therapeutically intervene, we have studied the allogeneic response to the mouse class I MHC molecule Ld. In this report, the therapeutic potential of a synthetic peptide derived from the TCR V beta 8 variable region that predominates in responses to Ld was tested. This V beta 8-derived peptide was found to dramatically and specifically block the in vivo and in vitro allogeneic response to Ld. Furthermore, this specific blocking is not dependent upon the presence of V beta 8+ effector cells nor does the V beta 8 peptide bind to the Ld ligand binding cleft. We propose that this peptide functions as an antagonist, competing with the native TCR for recognition of the Ld molecule.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	21
Volume Number	90
Language	English
Publisher	National Academy of Sciences
Publisher Date	1993-12-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Graft Survival Drug Effects Peptide Fragments Pharmacology Receptors, Antigen, T-Cell Immunology Skin Transplantation Amino Acid Sequence Animals Cell Line Haplotypes Histocompatibility Antigens Class I Histocompatibility Antigens Class II Mice Mice, Inbred BALB C Mice, Inbred C57BL Mice, Inbred Strains Molecular Sequence Data T-Lymphocytes, Cytotoxic Transplantation, Homologous Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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