NDLI: Neurologic disease induced in transgenic mice by cerebral overexpression of interleukin 6.

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Neurologic disease induced in transgenic mice by cerebral overexpression of interleukin 6.

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Neurologic disease induced in transgenic mice by cerebral overexpression of interleukin 6.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Oldstone, M. B. Inglis, J. D. Campbell, I. L. Mucke, L. Abraham, C. R. Masliah, E. Kemper, P.
Description	Author Affiliation: Campbell IL ( Department of Neuropharmacology, Scripps Research Institute, La Jolla, CA 92037.);
Abstract	Cytokines are thought to be important mediators in physiologic and pathophysiologic processes affecting the central nervous system (CNS). To explore this hypothesis, transgenic mice were generated in which the cytokine interleukin 6 (IL-6), under the regulatory control of the glial fibrillary acidic protein gene promoter, was overexpressed in the CNS. A number of transgenic founder mice and their offspring exhibited a neurologic syndrome the severity of which correlated with the levels of cerebral IL-6 expression. Transgenic mice with high levels of IL-6 expression developed severe neurologic disease characterized by runting, tremor, ataxia, and seizure. Neuropathologic manifestations included neuro-degeneration, astrocytosis, angiogenesis, and induction of acute-phase-protein production. These findings indicate that cytokines such as IL-6 can have a direct pathogenic role in inflammatory, infectious, and neurodegenerative CNS diseases.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	21
Volume Number	90
Language	English
Publisher	National Academy of Sciences
Publisher Date	1993-12-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Astrocytes Metabolism Brain Central Nervous System Diseases Genetics Gene Expression Interleukin-6 Biosynthesis RNA, Messenger Recombinant Fusion Proteins Animals Pathology Glial Fibrillary Acidic Protein Kidney Liver Mice Mice, Inbred C57BL Mice, Inbred Strains Mice, Transgenic Neovascularization, Pathologic Spleen Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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