NDLI: Growth-stimulatory monoclonal antibodies against human insulin-like growth factor I receptor.

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Growth-stimulatory monoclonal antibodies against human insulin-like growth factor I receptor.

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Growth-stimulatory monoclonal antibodies against human insulin-like growth factor I receptor.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Kasuya, J. Fujita-yamaguchi, Y. Li, S. L. Kato, J. Xiong, L.
Description	Author Affiliation: Xiong L ( Department of Molecular Genetics, Beckman Research Institute of the City of Hope, Duarte, CA 91010.);
Abstract	Monoclonal antibodies (mAbs) against purified human placental insulin-like growth factor I (IGF-I) receptors were prepared and characterized. Three IgG mAbs were specific for the human IGF-I receptor and displayed negligible crossreactivity with the human insulin receptor. They stimulated 125I-labeled IGF-I (125I-IGF-I) or 125I-IGF-II binding to purified human placental IGF-I receptors and to IGF-I receptors expressed in NIH 3T3 cells in contrast to the well-studied mAb alpha IR-3, which inhibits 125I-IGF-I or 125I-IGF-II binding to both forms of IGF-I receptors. The mAbs introduced in this study stimulated DNA synthesis in NIH 3T3 cells expressing human IGF-I receptors approximately 1.5-fold above the basal level and the IGF-I- or IGF-II-stimulated level. In contrast, alpha IR-3 inhibited both basal and IGF-I or IGF-II-stimulated DNA synthesis by approximately 30%. Inhibition of IGF-II-stimulated DNA synthesis by alpha IR-3 was as potent as its inhibition of IGF-I-stimulated DNA synthesis, although IGF-II binding to the IGF-I receptors was not inhibited by IGF-II as potently as was IGF-I. With the purified IGF-I receptors, both inhibitory and stimulatory mAbs were shown to activate autophosphorylation of the IGF-I receptor beta subunit and to induce microaggregation of the receptors. These results suggest that conformational changes resulting from receptor dimerization in the presence of either type of mAb may affect the signal-transducing function of the IGF-I receptor differently. These additional mAbs and alpha IR-3 immunoprecipitated nearly 90% of IGF-I binding activity from Triton X-100-solubilized human placental membranes, indicating that IGF-I receptor reactive with these mAbs is the major form of the IGF-I receptor in human placenta.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	12
Volume Number	89
Language	English
Publisher	National Academy of Sciences
Publisher Date	1992-07-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Antibodies, Monoclonal Insulin-Like Growth Factor I Metabolism Receptors, Cell Surface Immunology Physiology 3T3 Cells Adenosine Triphosphate Animals Cell Membrane Cross Reactions DNA Replication Insulin-Like Growth Factor II Kinetics Macromolecular Substances Methionine Mice Mice, Inbred BALB C Phosphorylation Placenta Pregnancy Receptor, Insulin Genetics Receptors, Somatomedin Transfection Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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