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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Kishimoto, T. Rosenfeld, M. G. Pearse, R. V. Lin, C. R. |
| Description | Author Affiliation: Kishimoto T ( Eukaryotic Regulatory Biology Program, University of California at San Diego, School of Medicine, La Jolla 92093-0648.); |
| Abstract | Corticotropin-releasing factor (CRF) mediates many critical aspects of the physiological response to stress. These effects are elicited by binding to specific high-affinity receptors, which are coupled to guanine nucleotide stimulatory factor (Gs)-response pathways. Recently, a gene encoding a receptor for CRF, expressed in pituitary and the central nervous system (PC-CRF receptor), was isolated and characterized. Here we report the identification and characterization of a second, distinct CRF receptor that is expressed primarily in heart and skeletal muscle and exhibits a specific ligand preference and antagonist sensitivity compared with the PC-CRF receptor. We refer to this second receptor as the heart/muscle (HM)-CRF receptor. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 4 |
| Volume Number | 92 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 1995-03-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Muscle, Skeletal Metabolism Myocardium Peptide Biosynthesis Receptors, Corticotropin-Releasing Hormone Biosynthesis Amino Acid Sequence Amphibian Proteins Animals Cloning, Molecular DNA, Complementary Mice Molecular Sequence Data Peptide Hormones Peptides Genetics Sequence Homology, Amino Acid Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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