NDLI: Possible proton relay pathways in cytochrome c oxidase.

Please wait, while we are loading the content...

Year: 2017 Volume: 114

Year: 2016 Volume: 113

Year: 2015 Volume: 112

Year: 2014 Volume: 111

Year: 2013 Volume: 110

Year: 2012 Volume: 109

Year: 2011 Volume: 108

Year: 2010 Volume: 107

Year: 2009 Volume: 106

Year: 2008 Volume: 105

Year: 2007 Volume: 104

Year: 2006 Volume: 103

Year: 2005 Volume: 102

Year: 2004 Volume: 101

Year: 2003 Volume: 100

Year: 2002 Volume: 99

Year: 2001 Volume: 98

Year: 2000 Volume: 97

Year: 1999 Volume: 96

Year: 1998 Volume: 95

Year: 1997 Volume: 94

Year: 1996 Volume: 93

Year: 1995 Volume: 92

Year: 1995 Volume: 92 Issue: 26

Year: 1995 Volume: 92 Issue: 25

Year: 1995 Volume: 92 Issue: 24

Year: 1995 Volume: 92 Issue: 23

Year: 1995 Volume: 92 Issue: 22

Year: 1995 Volume: 92 Issue: 21

Year: 1995 Volume: 92 Issue: 20

Year: 1995 Volume: 92 Issue: 19

Year: 1995 Volume: 92 Issue: 18

Year: 1995 Volume: 92 Issue: 17

Year: 1995 Volume: 92 Issue: 16

Year: 1995 Volume: 92 Issue: 15

Year: 1995 Volume: 92 Issue: 14

Year: 1995 Volume: 92 Issue: 13

Year: 1995 Volume: 92 Issue: 12

Year: 1995 Volume: 92 Issue: 11

Year: 1995 Volume: 92 Issue: 10

Year: 1995 Volume: 92 Issue: 9

Year: 1995 Volume: 92 Issue: 8

Year: 1995 Volume: 92 Issue: 7

Year: 1995 Volume: 92 Issue: 6

Year: 1995 Volume: 92 Issue: 5

Sexual selection in plants: pros and cons.

Dimensionless invariants from foraging theory's marginal value theorem.

Nitric oxide signaling to iron-regulatory protein: direct control of ferritin mRNA translation and transferrin receptor mRNA stability in transfected fibroblasts.

Theoretical predictions of folding pathways by using the proximity rule, with applications to bovine pancreatic trypsin inhibitor.

Angiogenesis: role of calcium-mediated signal transduction.

A macrophage receptor for oxidized low density lipoprotein distinct from the receptor for acetyl low density lipoprotein: partial purification and role in recognition of oxidatively damaged cells.

A mutation in the epidermal growth factor receptor in waved-2 mice has a profound effect on receptor biochemistry that results in impaired lactation.

Src homology 2 domain as a specificity determinant in the c-Abl-mediated tyrosine phosphorylation of the RNA polymerase II carboxyl-terminal repeated domain.

Long-term culture system for selective growth of human B-cell progenitors.

Opposing mechanisms of regulation of a G-protein-coupled inward rectifier K+ channel in rat brain neurons.

Autocrine regulation of toxin synthesis by Staphylococcus aureus.

The RNA-binding protein TIAR is translocated from the nucleus to the cytoplasm during Fas-mediated apoptotic cell death.

Hindrance of binding to class II major histocompatibility complex molecules by a single amino acid residue contiguous to a determinant leads to crypticity of the determinant as well as lack of response to the protein antigen.

Immunophilin FK506 binding protein associated with inositol 1,4,5-trisphosphate receptor modulates calcium flux.

Amyotrophic lateral sclerosis: human challenge for neuroscience.

Kinetic and affinity limits on antibodies produced during immune responses.

Early high-affinity neutralizing anti-viral IgG responses without further overall improvements of affinity.

Transport of proteins dissolved in organic solvents across biomimetic membranes.

Biological and structural characterization of a Ras transforming mutation at the phenylalanine-156 residue, which is conserved in all members of the Ras superfamily.

Evolution-like selection of fast-folding model proteins.

Yeast glycosylation mutants are sensitive to aminoglycosides.

Maintenance of an extrachromosomal plasmid vector in mouse embryonic stem cells.

Xenopus Gq alpha subunit activates the phosphatidylinositol pathway in Xenopus oocytes but does not consistently induce oocyte maturation.

Sexually dimorphic DNA demethylation in the promoter of the Slp (sex-limited protein) gene in mouse liver.

Intracellular interleukin 6 mediates platelet-derived growth factor-induced proliferation of nontransformed cells.

Real time imaging of transcriptional activity in live mouse preimplantation embryos using a secreted luciferase.

Targeted overexpression of luteinizing hormone in transgenic mice leads to infertility, polycystic ovaries, and ovarian tumors.

Development of anti-p185HER2 immunoliposomes for cancer therapy.

Evidence that carcinogenesis involves an imbalance between epigenetic high-frequency initiation and suppression of promotion.

Leukemia inhibitory factor protects against experimental lethal Escherichia coli septic shock in mice.

p53-mediated cellular response to DNA damage in cells with replicative hepatitis B virus.

Retinoblastoma gene product as a downstream target for a ceramide-dependent pathway of growth arrest.

The dif resolvase locus of the Escherichia coli chromosome can be replaced by a 33-bp sequence, but function depends on location.

Multiple members of the E2F transcription factor family are the products of oncogenes.

The U3 promoter region of the acutely lethal simian immunodeficiency virus clone smmPBj1.9 confers related biological activity on the apathogenic clone agm3mc.

Selective boron delivery to murine tumors by lipophilic species incorporated in the membranes of unilamellar liposomes.

An early increase in somatostatin mRNA expression in the frontal cortex of rhesus monkeys infected with simian immunodeficiency virus.

Identification of a Ca2+/calmodulin-dependent protein kinase II regulatory phosphorylation site in non-N-methyl-D-aspartate glutamate receptors.

Reduction of caveolin and caveolae in oncogenically transformed cells.

A diabetes-associated T-cell autoantigen maps to a telomeric locus on mouse chromosome 6.

Recognition of oxidatively damaged and apoptotic cells by an oxidized low density lipoprotein receptor on mouse peritoneal macrophages: role of membrane phosphatidylserine.

Cellular and humoral immune responses to adenoviral vectors containing factor IX gene: tolerization of factor IX and vector antigens allows for long-term expression.

Protein kinase C epsilon is localized to the Golgi via its zinc-finger domain and modulates Golgi function.

Comparison of genetically engineered herpes simplex viruses for the treatment of brain tumors in a scid mouse model of human malignant glioma.

Apoptosis and interleukin 7 gene expression in chronic B-lymphocytic leukemia cells.

Direct interaction and N-terminal phosphorylation of c-Jun by c-Mil/Raf.

Plasma albumin is a potent trigger of calcium signals and DNA synthesis in astrocytes.

Axon-induced mitogenesis of human Schwann cells involves heregulin and p185erbB2.

A mutation in the RCC1-related protein pim1 results in nuclear envelope fragmentation in fission yeast.

Glycinergic synaptic currents in Golgi cells of the rat cerebellum.

Bacteriophage T4 MotA and AsiA proteins suffice to direct Escherichia coli RNA polymerase to initiate transcription at T4 middle promoters.

Specific inhibition of herpes simplex virus DNA polymerase by helical peptides corresponding to the subunit interface.

Tension relaxation induced by pulse photolysis of caged ATP in partially crosslinked fibers from rabbit psoas muscle.

Acute hepatitis in rats expressing human hepatitis B virus transgenes.

Smooth muscle cell-derived carbon monoxide is a regulator of vascular cGMP.

Regulation of human retroviral latency by the NF-kappa B/I kappa B family: inhibition of human immunodeficiency virus replication by I kappa B through a Rev-dependent mechanism.

The Drosophila yolkless gene encodes a vitellogenin receptor belonging to the low density lipoprotein receptor superfamily.

A second N-acylhomoserine lactone signal produced by Pseudomonas aeruginosa.

Expression cloning of the cDNA for a polypeptide associated with rat hepatic sinusoidal reduced glutathione transport: characteristics and comparison with the canalicular transporter.

Functional dissection of circadian clock- and phytochrome-regulated transcription of the Arabidopsis CAB2 gene.

Regulation of leukocyte-endothelium interaction and leukocyte transendothelial migration by intercellular adhesion molecule 1-fibrinogen recognition.

Differential expression of SNAP-25 protein isoforms during divergent vesicle fusion events of neural development.

Expression of a human alpha-1,3/4-fucosyltransferase in the pit cell lineage of FVB/N mouse stomach results in production of Leb-containing glycoconjugates: a potential transgenic mouse model for studying Helicobacter pylori infection.

Tightly regulated, developmentally specific expression of the first open reading frame from LINE-1 during mouse embryogenesis.

Monocytes are required to prime peripheral blood T cells to undergo apoptosis.

Protective immunity against tuberculosis induced by vaccination with major extracellular proteins of Mycobacterium tuberculosis.

Transcription factor TFIIB and the vitamin D receptor cooperatively activate ligand-dependent transcription.

Segregation of cardiac and skeletal muscle-specific regulatory elements of the beta-myosin heavy chain gene.

Long-lived testosterone esters in the rat.

Cleavage without anchor addition accompanies the processing of a nascent protein to its glycosylphosphatidylinositol-anchored form.

Identification of a neural-specific cDNA, NPDC-1, able to down-regulate cell proliferation and to suppress transformation.

Biochemical evidence for the autophosphorylation and transphosphorylation of transforming growth factor beta receptor kinases.

Delineation of the minimal hepatitis B surface antigen-specific B- and T-cell epitope contained within an anti-idiotype-derived pentadecapeptide.

Inhibition of cell proliferation by the somatostatin analogue RC-160 is mediated by somatostatin receptor subtypes SSTR2 and SSTR5 through different mechanisms.

Mice deficient in cystathionine beta-synthase: animal models for mild and severe homocyst(e)inemia.

A mechanical strain-induced 1-aminocyclopropane-1-carboxylic acid synthase gene.

The fungal H(+)-ATPase from Neurospora crassa reconstituted with fusicoccin receptors senses fusicoccin signal.

Possible proton relay pathways in cytochrome c oxidase.

Display of peptides and proteins on the surface of bacteriophage lambda.

Tumor necrosis factor alpha rapidly activates the mitogen-activated protein kinase (MAPK) cascade in a MAPK kinase kinase-dependent, c-Raf-1-independent fashion in mouse macrophages.

Recombinant rat CBF-C, the third subunit of CBF/NFY, allows formation of a protein-DNA complex with CBF-A and CBF-B and with yeast HAP2 and HAP3.

The p150Glued component of the dynactin complex binds to both microtubules and the actin-related protein centractin (Arp-1).

Two short autoepitopes on the nuclear dot antigen are similar to epitopes encoded by the Epstein-Barr virus.

Mutants of Escherichia coli heat-labile toxin lacking ADP-ribosyltransferase activity act as nontoxic, mucosal adjuvants.

Altered phenotype and function of natural killer cells expressing the major histocompatibility complex receptor Ly-49 in mice transgenic for its ligand.

Integration of human papillomavirus type 16 DNA into the human genome leads to increased stability of E6 and E7 mRNAs: implications for cervical carcinogenesis.

Functional identification of the promoter for the gene encoding the alpha subunit of calcium/calmodulin-dependent protein kinase II.

A genetic locus of enterocyte effacement conserved among diverse enterobacterial pathogens.

Dopamine receptors in the substantia nigra are involved in the regulation of muscle tone.

Retroviral-mediated gene transfer corrects very-long-chain fatty acid metabolism in adrenoleukodystrophy fibroblasts.

Cytoplasmic inhibition of carotenoid biosynthesis with virus-derived RNA.

Detecting conserved regulatory elements with the model genome of the Japanese puffer fish, Fugu rubripes.

Scalp electrical potentials reflect regional cerebral blood flow responses during processing of written words.

Mechanistically different catalytic antibodies obtained from immunization with a single transition-state analog.

Structural characterization of a minimal functional transactivation domain from the human glucocorticoid receptor.

Mutant farnesyltransferase beta subunit of Saccharomyces cerevisiae that can substitute for geranylgeranyltransferase type I beta subunit.

The murine N-ras gene is not essential for growth and development.

Soluble type II interleukin 1 (IL-1) receptor binds and blocks processing of IL-1 beta precursor and loses affinity for IL-1 receptor antagonist.

A paradoxical regulation of the dopamine D3 receptor expression suggests the involvement of an anterograde factor from dopamine neurons.

Transient protein kinase C activation primes long-term depression and suppresses long-term potentiation of synaptic transmission in hippocampus.

Characterization of two nuclear mammalian homologous DNA-pairing activities that do not require associated exonuclease activity.

Differential expression of mRNAs for protein kinase inhibitor isoforms in mouse brain.

Translocation of the Escherichia coli transcription complex observed in the registers 11 to 20: 'jumping' of RNA polymerase and asymmetric expansion and contraction of the 'transcription bubble'.

Targeted gene transfer into hepatoma cells with lipopolyamine-condensed DNA particles presenting galactose ligands: a stage toward artificial viruses.

Human RanGTPase-activating protein RanGAP1 is a homologue of yeast Rna1p involved in mRNA processing and transport.

Site-directed mutagenesis studies of the high-affinity streptavidin-biotin complex: contributions of tryptophan residues 79, 108, and 120.

Caveolae from luminal plasmalemma of rat lung endothelium: microdomains enriched in caveolin, Ca(2+)-ATPase, and inositol trisphosphate receptor.

Molecular chaperones involved in protein degradation in the endoplasmic reticulum: quantitative interaction of the heat shock cognate protein BiP with partially folded immunoglobulin light chains that are degraded in the endoplasmic reticulum.

Identification of a protein complex that is required for nuclear protein import and mediates docking of import substrate to distinct nucleoporins.

Knockout of the mouse apolipoprotein B gene results in embryonic lethality in homozygotes and protection against diet-induced hypercholesterolemia in heterozygotes.

Mitogenic and melanogenic stimulation of normal human melanocytes by melanotropic peptides.

Year: 1995 Volume: 92 Issue: 4

Year: 1995 Volume: 92 Issue: 3

Year: 1995 Volume: 92 Issue: 2

Year: 1995 Volume: 92 Issue: 1

Year: 1994 Volume: 91

Year: 1993 Volume: 90

Year: 1992 Volume: 89

Year: 1991 Volume: 88

Year: 1990 Volume: 87

Year: 1989 Volume: 86

Year: 1988 Volume: 85

Year: 1987 Volume: 84

Year: 1986 Volume: 83

Year: 1985 Volume: 82

Year: 1984 Volume: 81

Year: 1983 Volume: 80

Year: 1982 Volume: 79

Year: 1981 Volume: 78

Year: 1980 Volume: 77

Year: 1979 Volume: 76

Year: 1978 Volume: 75

Year: 1977 Volume: 74

Year: 1976 Volume: 73

Year: 1975 Volume: 72

Year: 1974 Volume: 71

Year: 1973 Volume: 70

Year: 1972 Volume: 69

Year: 1971 Volume: 68

Year: 1970 Volume: 67

Year: 1970 Volume: 66

Year: 1970 Volume: 65

Year: 1969 Volume: 64

Year: 1969 Volume: 63

Year: 1969 Volume: 62

Year: 1968 Volume: 61

Year: 1968 Volume: 60

Year: 1968 Volume: 59

Year: 1967 Volume: 58

Year: 1967 Volume: 57

Year: 1966 Volume: 56

Year: 1966 Volume: 55

Possible proton relay pathways in cytochrome c oxidase.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Shapleigh, J. Schmidt, E. Ferguson-miller, S. García-horsman, A. Fetter, J. R. Hosler, J. Babcock, G. T. Thomas, J. W. Qian, J. Gennis, R. B.
Description	Author Affiliation: Fetter JR ( Department of Biochemistry, Michigan State University, East Lansing 48824.);
Abstract	As the final electron acceptor in the respiratory chain of eukaryotic and many prokaryotic organisms, cytochrome c oxidase (EC 1.9.3.1) catalyzes the reduction of oxygen to water and generates a proton gradient. To test for proton pathways through the oxidase, site-directed mutagenesis was applied to subunit I of the Rhodobacter sphaeroides enzyme. Mutants were characterized in three highly conserved regions of the peptide, comprising possible proton loading, unloading, and transfer sites: an interior loop between helices II and III (Asp132Asn/Ala), an exterior loop between helices IX and X (His411Ala, Asp412Asn, Thr413Asn, Tyr414Phe), and the predicted transmembrane helix VIII (Thr352Ala, Pro358Ala, Thr359Ala, Lys362Met). Most of the mutants had lower activity than wild type, but only mutants at residue 132 lost proton pumping while retaining electron transfer activity. Although electron transfer was substantially inhibited, no major structural alteration appears to have occurred in D132 mutants, since resonance Raman and visible absorbance spectra were normal. However, lower CO binding (70-85% of wild type) suggests some minor change to the binuclear center. In addition, the activity of the reconstituted Asp132 mutants was inhibited rather than stimulated by ionophores or uncoupler. The inhibition was not observed with the purified enzyme and a direct pH effect was ruled out, suggesting an altered response to the electrical or pH gradient. The results support an important role for the conserved II-III loop in the proton pumping process and are consistent with the possibility of involvement of residues in helix VIII and the IX-X loop.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	5
Volume Number	92
Language	English
Publisher	National Academy of Sciences
Publisher Date	1995-04-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Electron Transport Complex IV Metabolism Proton-Translocating ATPases Amino Acid Sequence Bacterial Proteins Chemistry Binding Sites Carbonyl Cyanide M-Chlorophenyl Hydrazone Pharmacology Electron Transport Hydrogen-Ion Concentration Molecular Sequence Data Mutagenesis, Site-Directed Rhodobacter Sphaeroides Enzymology Spectrum Analysis, Raman Structure-Activity Relationship Valinomycin Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302

See location in the Map
03222 282435
Mail: support@ndl.gov.in

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in