NDLI: Reduction of caveolin and caveolae in oncogenically transformed cells.

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Reduction of caveolin and caveolae in oncogenically transformed cells.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Koleske, A. J. Baltimore, D. Lisanti, M. P.
Description	Author Affiliation: Koleske AJ ( Department of Biology, Massachusetts Institute of Technology, Cambridge 02139.);
Abstract	Caveolae are flask-shaped non-clathrin-coated invaginations of the plasma membrane. In addition to the demonstrated roles for caveolae in potocytosis and transcytosis, caveolae may regulate the transduction of signals from the plasma membrane. Transformation of NIH 3T3 cells by various oncogenes leads to reductions in cellular levels of caveolin, a principal component of the protein coat of caveolae. The reduction in caveolin correlates very well with the size of colonies formed by these transformed cells when grown in soft agar. Electron microscopy reveals that caveolae are morphologically absent from these transformed cell lines. These observations suggest that functional alterations in caveolae may play a critical role in oncogenic transformation, perhaps by disrupting contact inhibition in transformed cells.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	5
Volume Number	92
Language	English
Publisher	National Academy of Sciences
Publisher Date	1995-04-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Caveolins Cell Transformation, Neoplastic Metabolism Ultrastructure Membrane Proteins 3T3 Cells Animals Caveolin 1 Cell Division Cell Membrane Gene Expression Regulation, Neoplastic HSP70 Heat-Shock Proteins Genetics In Vitro Techniques Mice Oncogenes RNA, Messenger Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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