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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Hanai, R. Caron, P. R. Wang, J. C. |
| Description | Author Affiliation: Hanai R ( Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02139, USA.); |
| Abstract | A human cDNA encoding a protein homologous to the Escherichia coli DNA topoisomerase I subfamily of enzymes has been identified through cloning and sequencing. Expressing the cloned human cDNA in yeast (delta)top1 cells lacking endogenous DNA topoisomerase I yielded an activity in cell extracts that specifically reduces the number of supercoils in a highly negatively supercoiled DNA. On the basis of these results, the human gene containing the cDNA sequence has been denoted TOP3, and the protein it encodes has been denoted DNA topoisomerase III. Screening of a panel of human-rodent somatic hybrids and fluorescence in situ hybridization of cloned TOP3 genomic DNA to metaphase chromosomes indicate that human TOP3 is a single-copy gene located at chromosome 17p11.2-12. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 8 |
| Volume Number | 93 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 1996-06-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | DNA Topoisomerases, Type I Genetics Genes Animals Chromosome Mapping Chromosomes, Human, Pair 17 Cloning, Molecular Cricetinae Metabolism DNA, Complementary DNA, Superhelical Escherichia Coli Enzymology Hybrid Cells In Vitro Techniques Mice Molecular Sequence Data Recombinant Proteins Saccharomyces Cerevisiae Sequence Homology, Amino Acid Comparative Study Research Support, U.S. Gov't, P.H.S. Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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