NDLI: Functional protection of dystrophic mouse (mdx) muscles after adenovirus-mediated transfer of a dystrophin minigene.

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Functional protection of dystrophic mouse (mdx) muscles after adenovirus-mediated transfer of a dystrophin minigene.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Maréchal, G. Ragot, T. Perricaudet, M. Gillis, J. M. Deconinck, N.
Description	Author Affiliation: Deconinck N ( Départment de Physiologie, Université Catholique de Louvain, Brussels,Belgium.);
Abstract	Fast skeletal muscles of mdx (X chromosome-linked muscular dystrophy) mice were injected after birth with a recombinant adenovirus containing a minidys- trophin gene, a 6.3-kbp cDNA coding for the N- and C-terminal ends of dystrophin. Adult muscles were challenged by forced lengthening during tetanic contractions. Stretch-induced mechanical and histological damages were much reduced in injected muscles, in direct proportion of the Miniber of fibers expressing minidystrophin. Damaged fibers were preferentially found among minidystrophin-negative regions. Minidystrostrophin confers an important functional and structural protection of limb muscles against high mechanical stress, even after a partial somatic gene transfer.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	8
Volume Number	93
Language	English
Publisher	National Academy of Sciences
Publisher Date	1996-06-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Dystrophin Genetics Gene Transfer Techniques Genetic Therapy Muscular Dystrophy, Animal Therapy Adenoviridae Animals Genetic Vectors In Vitro Techniques Mice Mice, Inbred Mdx Muscle Contraction Muscle Fibers, Fast-Twitch Physiology Muscle, Skeletal Pathology Physiopathology Stress, Mechanical Research Support, Non-U.S. Gov't Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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